Henk-Jan Guchelaar at Leiden University Medical Center - Research Interests, Publications & Academic Profile

Henk-Jan Guchelaar

Leiden University Medical Center

Netherlands

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Research Interests

Pharmacology

100%

Pharmacotherapy

80%

Pharmacometrics

60%

Medical Science

50%

Adverse Drug Reaction

30%

Pharmacogenomic

30%

Targeted Therapy

30%

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Articles18

Model-Informed Development of a Cost-Saving Dosing Regimen for Sacituzumab Govitecan

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Year:

2024

Quantitative modeling of tumor dynamics and development of drug resistance in non‐small cell lung cancer patients treated with erlotinib

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Year:

2024

Mapping the Pharmacogenetic Landscape in a Ugandan Population: Implications for Personalized Medicine in an Underrepresented Population

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Year:

2024

Nonlinear Mixed‐Effects Model of Z‐Endoxifen Concentrations in Tamoxifen‐Treated Patients from the CEPAM Cohort

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2024

A Genome‐Wide Association Study of Endoxifen Serum Concentrations and Adjuvant Tamoxifen Efficacy in Early‐Stage Breast Cancer Patients

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2024

Inflammation altered correlation between CYP2C19 genotype and CYP2C19 activity in patients receiving voriconazole

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Year:

2024

Personalized Chronomodulated 5‐Fluorouracil Treatment: A Physiologically‐Based Pharmacokinetic Precision Dosing Approach for Optimizing Cancer Therapy

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2024

A Nomogram to Predict Severe Toxicity in DPYD Wild‐Type Patients Treated With Capecitabine‐Based Anticancer Regimens

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2024

UGT1A1 genotype-guided dosing of irinotecan: time to prioritize patient safety

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Year:

2023

Development and Bioequivalence of 3D‐Printed Medication at the Point‐of‐Care: Bridging the Gap Toward Personalized Medicine

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2023

Response to “Plasma Uracil as a DPD Phenotyping Test: Pre‐analytical Handling Matters”

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Year:

2023

Reply to: Temporary Like Achilles: Pre‐emptive germline pharmacogenetic testing

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Year:

2023

Genome-Wide Analyses of Nephrotoxicity in Platinum-Treated Cancer Patients Identify Association with Genetic Variant in RBMS3 and Acute Kidney Injury

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Year:

2022

Application of Electronic Health Record Text Mining: Real-World Tolerability, Safety, and Efficacy of Adjuvant Melanoma Treatments

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Year:

2022

Genome-Wide Meta-Analysis Identifies Variants in DSCAM and PDLIM3 That Correlate with Efficacy Outcomes in Metastatic Renal Cell Carcinoma Patients Treated with Sunitinib

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Year:

2022

The Potential Application of Extracellular Vesicles from Liquid Biopsies for Determination of Pharmacogene Expression

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2022

3D Printing of Pediatric Medication: The End of Bad Tasting Oral Liquids?—A Scoping Review

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Year:

2022

Genotyping for HLA Risk Alleles to Prevent Drug Hypersensitivity Reactions: Impact Analysis

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Year:

2021

Collaborators12

Marieke Coenen

Associate Professor Pharmacogenetics

Erasmus MC

NETHERLANDS

Dirk Jan A. R. Moes

Leiden University Medical Center

NETHERLANDS

Manuel Corpas

Lecturer in Genomics

University of Westminster

UNITED KINGDOM

Kirsten J. M. Schimmel

NETHERLANDS

Michel M. van den Heuvel

Radboud University Medical Center

NETHERLANDS

Thorsten Lehr

Professor Clinical Pharmacy

Saarland University

GERMANY

Brenda de Winter

Hospital Pharmacist - Assistant Professor

Erasmus University Medical Center

NETHERLANDS

J.G.C. van Hasselt

Associate professor

Leiden University

NETHERLANDS

Hans Gelderblom

Prof.dr.

Leiden University Medical Center

NETHERLANDS

Ellen H. W. Kapiteijn

Leiden University Medical Center

NETHERLANDS

Teun van Gelder

Professor in Drug Discovery & Development

Leiden University Medical Center

NETHERLANDS

Jesse Swen

Full professor of clinical pharmacy, in particular translational pharmacogenetics

Leiden University Medical Center

NETHERLANDS

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