This PhD project at the University of Edinburgh’s School of Biological Sciences focuses on the synthesis and catalysis of bacterial nanoparticles. Metal nanoparticle synthesis has been observed in several bacterial species, but the mechanisms underlying their formation remain poorly understood. Building on previous research that demonstrated methods to manipulate nanoparticle size and yield in native bacterial producers, this project aims to further explore the catalytic potential of these biogenic nanoparticles, particularly in the context of green chemistry and bioremediation.

The research will involve tailoring nanoparticles for specific catalytic applications by optimizing their synthetic pathways using genetic engineering techniques. The project will also provide new mechanistic insights into nanoparticle formation and require comprehensive nanoparticle characterisation. Applications of the research include generating nanoparticles from waste materials and exploring their use in environmental remediation.

Applicants should have a strong background in biological sciences, biochemistry, biotechnology, genetic engineering, microbiology, or molecular biology. Experience with nanoparticle synthesis, catalysis, or genetic manipulation is advantageous. The project is supervised by Professor Louise Horsfall, an expert in the field, and is supported by the Darwin Trust-funded PhD studentship, which is open to International and EU candidates. The studentship covers full tuition fees and provides an annual stipend of £22,700 for the 2025-26 academic year.

To apply, candidates should submit an application to the School’s Biological Sciences PhD programme via the University’s EUCLID admissions portal, clearly stating the project title, supervisor, and anticipated funding source. Those seeking Darwin Trust funding must also submit a separate application to the Darwin Trust. Prospective students are encouraged to contact Professor Horsfall to discuss their interest in the project before applying. The application deadline is 7 January 2026, with a start date of 1 October 2026.

For further information, including project details, eligibility, and application guidance, please visit the institutional website or the FindAPhD project page. Key references for the project include recent publications in JACS Au, Green Chemistry, and Microbiology, highlighting the group’s expertise in biogenic nanoparticle catalysis and proteomics.