This postdoctoral position at the University of Strasbourg offers an exciting opportunity to work at the intersection of theoretical and experimental biological physics. The project, based in the GMGM UMR 7156 laboratory, focuses on unraveling the genotype-phenotype relationship—a fundamental question in biology with broad implications for understanding cellular resistance to stressors such as antibiotics and drug treatments. The research leverages recent advances in physics and mathematics to approach this challenge through a multidisciplinary lens, integrating molecular and cellular biology, single-cell physics, microfluidics, and mathematical modeling. The successful candidate will join the Quantitative Biology of Cellular Growth team, which investigates the mechanisms driving replicative senescence and physiological responses to oxidative stress and starvation in the model organism Saccharomyces cerevisiae (yeast). The lab is renowned for developing microfluidic devices that enable non-destructive single-cell imaging under controlled conditions, combined with advanced molecular genetic methods. This environment provides a unique platform for high-throughput single-cell phenotyping and dynamic monitoring of cellular processes. Research activities will include conducting stress-related microfluidic experiments on yeast, experimentally validating and refining numerical ODE models of yeast behavior, performing qualitative and bifurcation analyses of these models, and running stochastic simulations of noisy dynamics. The role also involves reiterating and redesigning experimental protocols as needed, as well as documenting results in scientific articles and simulation software. Applicants should possess a PhD (or equivalent) in a relevant field, with no more than two years of postdoctoral experience. Essential qualifications include a strong foundation in mathematical analysis, ODEs, stochastic ODEs (especially Langevin dynamics), systems biology, and experimental molecular biology. Operational skills in microfluidic fabrication, fluorescent microscopy, basic molecular biology techniques, programming (Python, MATLAB), and scientific writing (LaTeX) are required. The position calls for a candidate with both theoretical and experimental expertise, ready to contribute to an ambitious interdisciplinary project. The contract is for 12 months, full-time, starting January 12, 2026. The position is based in Strasbourg, France. To apply, candidates should send a CV, cover letter, and diploma to Dr. Anton Zadorin (azadorin@unistra.fr). Internal application forms may be required. For more information, visit the University of Strasbourg website or the position posting . The application deadline is December 10, 2025.