Jane Holmes at University of Oxford - Research Interests, Publications & Academic Profile

Jane Holmes

University of Oxford

United Kingdom

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Research Interests

Pharmacotherapy

80%

Pharmacology

50%

Oncology

40%

Antiviral Therapy

20%

Adjuvant Therapy

20%

Neoadjuvant Therapy

20%

Targeted Therapy

20%

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Recent Grants

Grant: Open

Optimising cultural expeRIences for mental health in underrepresented younG people onlINe (ORIGIN)

Open Date: 2023-05-01

Close Date: 2028-04-30

Grant: Close

A randomised controlled trial of TRANSrectal biopsy versus Local Anaesthetic Transperineal biopsy Evaluation (TRANSLATE) of potential clinically significant prostate cancer

Open Date: 2021-04-01

Close Date: 2023-10-31

Grant: Close

A phase 1 trial of a retinoic acid receptor beta agonist for the treatment of spinal cord injury

Open Date: 2018-02-01

Close Date: 2021-09-29

Grant: Close

CRUK/17/015 CEDAR: Chemoradiation with Enadenotucirev as a radiosensitiser in locally advanced colorectal cancer

Open Date: 2017-10-01

Close Date: 2022-03-31

Articles13

Cost-utility analysis of molnupiravir plus usual care versus usual care alone as early treatment for community-based adults with COVID-19 and increased risk of adverse outcomes in the UK PANORAMIC trial.

Article Link

Year:

2024

Platform adaptive trial of novel antivirals for early treatment of COVID-19 In the community (PANORAMIC): protocol for a randomised, controlled, open-label, adaptive platform trial of community novel antiviral treatment of COVID-19 in people at increased risk of more severe disease

Article Link

Year:

2023

Phase 1 safety, tolerability, pharmacokinetics and pharmacodynamic results of KCL-286, a novel retinoic acid receptor-β agonist for treatment of spinal cord injury, in male healthy participants.

Article Link

Year:

2023

CHARIOT: a phase I study of berzosertib with chemoradiotherapy in oesophageal and other solid cancers using time to event continual reassessment method.

Article Link

Year:

2023

Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial

Article Link

Year:

2022

Visualising harms in publications of randomised controlled trials: consensus and recommendations.

Article Link

Year:

2022

Effect of moderate to high intensity aerobic exercise on blood pressure in young adults: The TEPHRA open, two-arm, parallel superiority randomized clinical trial.

Article Link

Year:

2022

Early phase clinical trials extension to guidelines for the content of statistical analysis plans.

Article Link

Year:

2022

A multicentre retrospective review of SABR reirradiation in rectal cancer recurrence.

Article Link

Year:

2021

Mitochondrial Inhibitor Atovaquone Increases Tumor Oxygenation and Inhibits Hypoxic Gene Expression in Patients with Non-Small Cell Lung Cancer.

Article Link

Year:

2021

Randomised phase II trial of olaparib, chemotherapy or olaparib and cediranib in patients with platinum-resistant ovarian cancer (OCTOVA): a study protocol

Article Link

Year:

2021

A Bayesian phase 2 model based adaptive design to optimise antivenom dosing: Application to a dose-finding trial for a novel Russell's viper antivenom in Myanmar.

Article Link

Year:

2020

Practicalities in running early-phase trials using the time-to-event continual reassessment method (TiTE-CRM) for interventions with long toxicity periods using two radiotherapy oncology trials as examples.

Article Link

Year:

2020

Collaborators17

Chen Ji

Associate Professor

University of Warwick

UNITED KINGDOM

Melissa Dobson

University of Oxford

UNITED KINGDOM

Philip Evans

Professor of Primary Care Research

University of Exeter

UNITED KINGDOM

Jienchi Dorward

Academic Clinical Lecturer

University of Oxford

UNITED KINGDOM

Jonathan P. T. Corcoran

King’s College London

UNITED KINGDOM

Séan Micheal O'Cathail

University of Glasgow

UNITED KINGDOM

Simon Royal

UNITED KINGDOM

Jon Dickson

University of Sheffield

UNITED KINGDOM

HANA HASSANIN

Associate Professor in Translational and Experimental Medicine and Director of Surrey Clinical Research Facility

University of Surrey

UNITED KINGDOM

Mark Lown

University of Southampton

UNITED KINGDOM

Victoria Homer

University of Birmingham

UNITED KINGDOM

Alexander Ooms

University of Oxford

UNITED KINGDOM

Timothy Stanley Maughan

Professor of Clinical Oncology, CRUK/MRC Oxford Institute for Radiation Oncology

University of Oxford

UNITED KINGDOM

Azhar Zafar

Senior Lecturer

UNITED KINGDOM

Kerenza Hood

UNITED KINGDOM

Haroon Ahmed

Senior Clinical Lecturer

Cardiff University

UNITED KINGDOM

Najib M Rahman

Professor of Respiratory Medicine

University of Oxford

UNITED KINGDOM

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