Kelvin Luk at University of Pennsylvania - Research Interests, Publications & Academic Profile

Kelvin Luk

Research Associate Professor

University of Pennsylvania

United States

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Research Interests

Neurology

40%

Computational Neuroscience

40%

Parkinson's Disease

100%

Neurodegenerative Disease

40%

Mouse Genetics

40%

Neuroprotection

30%

Neuropharmacology

30%

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Articles16

Tau maturation in the clinicopathological spectrum of Lewy body and Alzheimer's disease

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Year:

2024

Neuroinflammatory gene expression profiles of reactive glia in the substantia nigra suggest a multidimensional immune response to alpha synuclein inclusions

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Year:

2024

Transcriptomic profiling of early synucleinopathy in rats induced with preformed fibrils

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Year:

2024

Developmental exposure to the Parkinson’s disease-associated organochlorine pesticide dieldrin alters dopamine neurotransmission in α-synuclein pre-formed fibril (PFF)-injected mice

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Year:

2023

α-Synuclein aggregates amplified from patient-derived Lewy bodies recapitulate Lewy body diseases in mice

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Year:

2023

Combining fibril‐induced alpha‐synuclein aggregation and 6‐hydroxydopamine in a mouse model of Parkinson's disease and the effect of cerebral dopamine neurotrophic factor on the induced neurodegeneration

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Year:

2023

A 14-day pulse of PLX5622 modifies α-synucleinopathy in preformed fibril-infused aged mice of both sexes

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Year:

2023

A Novel Brain PET Radiotracer for Imaging Alpha Synuclein Fibrils in Multiple System Atrophy

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Year:

2023

Identification of a Putative α-synuclein Radioligand Using an in silico Similarity Search

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Year:

2023

The variance in phosphorylated, insoluble ⍺-synuclein in humans, rats, and mice is not mainly driven by biological sex

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Year:

2023

Dopamine neurons exhibit emergent glutamatergic identity in Parkinson’s disease

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Year:

2022

Striatal Afferent BDNF Is Disrupted by Synucleinopathy and Partially Restored by STN DBS

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Year:

2021

Developmental exposure to the organochlorine pesticide dieldrin causes male-specific exacerbation of α-synuclein-preformed fibril-induced toxicity and motor deficits

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Year:

2020

Snca-GFP Knock-In Mice Reflect Patterns of Endogenous Expression and Pathological Seeding

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Year:

2020

Cell-to-Cell Transmission of Tau and α-Synuclein

Article Link

Year:

2020

Characterization of novel conformation-selective α-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease

Article Link

Year:

2020

Collaborators11

Zachary Freyberg

Associate Professor

University of Pittsburgh

UNITED STATES

Aastha Singh

University of Helsinki

FINLAND

Jack Lipton

Professor and Founding Chair

Michigan State University

UNITED STATES

Eric Ramsson

Associate Professor

Grand Valley State University

UNITED STATES

Katheryn Alexandra Quilico Cousins

Research Assistant Professor

University of Pennsylvania

UNITED STATES

Caryl E. Sortwell

UNITED STATES

Masato Koike

Professor and Chairman

Juntendo University Graduate School of Medicine

JAPAN

Maiko Uemura

Program-Specific Assistant Professor

Kyoto University

JAPAN

Thomas Steinkellner

Assistant Professor

Medical University of Vienna

AUSTRIA

Alison Bernstein

Assistant Professor

Rutgers University - Busch Campus

UNITED STATES

Thomas Hnasko

Associate Professor

University of California, San Diego

UNITED STATES

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