A postdoctoral position is available in Professor Mark Howarth's group at the University of Cambridge Department of Pharmacology, funded by BBSRC. The Howarth group is renowned for its work in synthetic biology, biotechnology, and entrepreneurship, with a particular focus on protein engineering. The project centers on developing a diverse array of protein superglues, such as SpyTag and SpyCatcher, which are innovative molecular tools created by the lab. SpyTag forms an irreversible covalent bond with SpyCatcher, enabling robust molecular assembly for applications in medicine, biotechnology, and fundamental research. These tools have been widely adopted globally and have reached clinical trials. The successful candidate will engineer new Tags/Catchers with selective and rapid reactions, facilitating the construction of novel devices both in cells and in vitro. Depending on the postdoc's interests, the project may address challenges in gene therapy, cancer cell therapy, vaccine development for global health, green biotransformation, or diagnostics. The role involves directed evolution, protein optimization, molecular biology, and biophysics, with opportunities to learn and apply AI and machine learning tools for protein design. Training in additional methods such as cell biology and structure determination will be provided as needed. Responsibilities include managing research activities, generating high-quality data, devising new project approaches, drafting scientific manuscripts, and potentially supervising Masters or PhD students. Candidates should have or be near completion of a PhD in molecular biosciences, with substantial experience in recombinant protein expression or cell biology. Strong communication skills, enthusiasm for science, and the ability to work both independently and collaboratively are essential. The position is funded for 36 months, with a salary of £33,002 - £35,608 for Research Assistants (if PhD not yet awarded) and £37,694- £46,049 for Research Associates (upon PhD award), with the possibility of supplementing income through undergraduate teaching. The University of Cambridge is committed to equality, diversity, and inclusion, and all employees must be eligible to live and work in the UK.

This postdoctoral position in the Department of Pharmacology at the University of Cambridge offers an exciting opportunity to join Professor Mark Howarth's research group, funded by BBSRC. The group is renowned for its work in synthetic biology, biotechnology, and entrepreneurship, with a particular focus on protein engineering. The project centers on the development of a diverse array of protein superglues, such as SpyTag and SpyCatcher, which are innovative molecular tools created by the Howarth lab. These tools enable irreversible covalent bonding between proteins, facilitating molecular assembly for a wide range of applications in medicine, biotechnology, and fundamental research. SpyTag technology has been widely adopted globally, including in clinical trials. The successful candidate will engineer new Tags/Catchers with rapid and selective reactions, enabling robust construction of devices both in cells and in vitro. Depending on the candidate's interests, the project may address challenges in gene therapy, cancer cell therapy, vaccine development for global health, green biotransformation, or diagnostics. The role involves directed evolution, protein optimisation, molecular biology, and biophysics, with support for developing skills in AI and machine learning for protein design. Training in additional methods such as cell biology and structure determination will be provided as needed. Responsibilities include managing research activities, generating high-quality data, devising new project approaches, drafting scientific manuscripts, and potentially supervising Master’s or PhD students. Applicants should hold or be near completion of a PhD in molecular biosciences and possess substantial experience in recombinant protein expression or cell biology. Strong communication skills, enthusiasm for science, and the ability to work collaboratively and independently are essential. The position is fixed-term for 36 months, with a salary range of £33,002 - £46,049, and opportunities for salary supplementation through undergraduate teaching. Candidates who have not yet been awarded their PhD will be appointed as Research Assistant, with promotion upon PhD completion. The University of Cambridge is committed to equality, diversity, and inclusion, and all employees must be eligible to live and work in the UK. Applications are submitted online, with further details available on the university’s job portal.