Richard Davis at Leiden University Medical Center - Research Interests, Publications & Academic Profile

Richard Davis

Leiden University Medical Center

Netherlands

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Research Interests

Cell Biology

80%

Tissue Engineering

80%

Stem Cell Biology

40%

Stem Cell Research

30%

Genome Editing

30%

Electrophysiology

30%

Calcium Homeostasis

30%

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Articles15

Validating human induced pluripotent stem cell-specific quality control tests for the release of an intermediate drug product in a Good Manufacturing Practice quality system

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Year:

2024

STRAIGHT-IN: a platform for rapidly generating panels of genetically modified human pluripotent stem cell lines

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Year:

2024

Three-dimensional cardiac models: a pre-clinical testing platform

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Year:

2024

Chronic Mexiletine Administration Increases Sodium Current in Non-Diseased Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

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Year:

2024

Genome-wide Cas9-mediated screening of essential non-coding regulatory elements via libraries of paired single-guide RNAs

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Year:

2024

Global Meta‐Analysis of Organoid and Organ‐on‐Chip Research

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Year:

2023

Beneficial effects of chronic mexiletine treatment in a human model of SCN5A overlap syndrome

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Year:

2023

Generation of AAVS1 and CLYBL STRAIGHT-IN v2 acceptor human iPSC lines for integrating DNA payloads

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Year:

2023

Maturation of hiPSC-derived cardiomyocytes promotes adult alternative splicing of SCN5A and reveals changes in sodium current associated with cardiac arrhythmia

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Year:

2022

STRAIGHT-IN enables high-throughput targeting of large DNA payloads in human pluripotent stem cells

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Year:

2022

Optogenetic Reporters Delivered as mRNA Facilitate Repeatable Action Potential and Calcium Handling Assessment in Human iPSC-Derived Cardiomyocytes

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Year:

2022

Generation, functional analysis and applications of isogenic three-dimensional self-aggregating cardiac microtissues from human pluripotent stem cells.

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Year:

2021

Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations.

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Year:

2021

The Linkage Phase of the Polymorphism KCNH2-K897T Influences the Electrophysiological Phenotype in hiPSC Models of LQT2

Article Link

Year:

2021

CRISPR/Cas9-Mediated Introduction of Specific Heterozygous Mutations in Human Induced Pluripotent Stem Cells.

Article Link

Year:

2021

Collaborators9

Elisabetta Cerbai

Professor

Università degli Studi di Napoli Federico II

ITALY

Valeria V Orlova

Leiden University Medical Center

NETHERLANDS

Stefan Krauss

Professor; Centre director

University of Oslo

NORWAY

Giulia Campostrini

Leiden University Medical Center

NETHERLANDS

Hae-Won Uh

Associate Professor

Universitair Medisch Centrum Utrecht

NETHERLANDS

Françoise Carlotti

Associate Professor

Leiden University Medical Center

NETHERLANDS

Ton Rabelink

professor

Leiden University

NETHERLANDS

Milena Bellin

Assistant Professor

Leiden University Medical Center

NETHERLANDS

Susan Kloet

Assistant Professor - Head, Leiden Genome Technology Center

Leiden University Medical Center

NETHERLANDS

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