Ruben ArteroRuben Artero
11 months ago
Oligonucleotide-based therapies for myotonic dystrophy University of Valencia in Spain
Degree Level
PhD
Field of study
Neuroscience
Funding
Funded through the ENTRY-DM MSCA multidisciplinary doctoral network
Deadline
Expired
Country
Spain
University
University of Valencia
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Where to contact
Official Email
Keywords
Neuroscience
Cell Biology
Physiology
Molecular Biology
Biomedical Engineering
Biology
Rna Biology
Neuropsychology
Biopharmaceutics
Omics
Genomic
Rna Therapeutics
Muscular Atrophy
Biomedicine
msc
About this position
We participate in ENTRY-DM, an MSCA multidisciplinary doctoral network aimed at developing oligonucleotide-based therapies and preparing clinical trials in myotonic dystrophy, through advanced doctoral training. It brings together 11 European laboratories and 18 international partners with expertise in disciplines as varied as medicinal chemistry, genetics, multi-omics, bioengineering and neuropsychology. The network is recruiting 14 doctoral candidates through Euraxess under the leadership of Mario Gomes-Pereira. Within the network, our laboratory is seeking two Doctoral Candidates (DC) who will enjoy a dynamic environment at the University of Valencia and close contact with ARTHEX Biotech, a spin-off company from our laboratory.
DC6 will focus on understanding the mechanisms by which MBNL translational repressor miRNAs are misregulated in DM1, their contribution to the disease, and how DMPK levels change in response to antimiRs. You will use muscle models such as immortalized patient-derived cells and human primary myoblasts.
DC9 will aim to discover means to enhance therapeutic antisense oligonucleotides by improving cellular uptake and endosomal escape, including genetic and drug screens using reporter cell lines. Effective approaches will be prioritized, and mechanisms of action will be defined. Results will be validated in DM1 disease models, evaluating hallmark features like RNA foci, and muscle strength using patient-derived cells and transgenic mice.
Candidate Profile: We seek a highly motivated and ambitious candidate with a strong background in genetics and cellular biology, particularly in RNA-based therapeutics. The ideal candidate should hold a Master’s degree in Molecular Life Sciences, Physiology, Biomedical Sciences, or a related field, with hands-on experience in gene and protein quantification techniques, immunofluorescence, and cell culturing.
Application Process (before deadline May 30th): Submit a single PDF document to Ruben Artero (DC6; [email protected] ), or Arturo López Castel (DC9; [email protected] ), and [email protected] , including your CV, motivation letter, academic certificates, proof of English proficiency, national identity card, and two recommendation letters.
DC6 will focus on understanding the mechanisms by which MBNL translational repressor miRNAs are misregulated in DM1, their contribution to the disease, and how DMPK levels change in response to antimiRs. You will use muscle models such as immortalized patient-derived cells and human primary myoblasts.
DC9 will aim to discover means to enhance therapeutic antisense oligonucleotides by improving cellular uptake and endosomal escape, including genetic and drug screens using reporter cell lines. Effective approaches will be prioritized, and mechanisms of action will be defined. Results will be validated in DM1 disease models, evaluating hallmark features like RNA foci, and muscle strength using patient-derived cells and transgenic mice.
Candidate Profile: We seek a highly motivated and ambitious candidate with a strong background in genetics and cellular biology, particularly in RNA-based therapeutics. The ideal candidate should hold a Master’s degree in Molecular Life Sciences, Physiology, Biomedical Sciences, or a related field, with hands-on experience in gene and protein quantification techniques, immunofluorescence, and cell culturing.
Application Process (before deadline May 30th): Submit a single PDF document to Ruben Artero (DC6; [email protected] ), or Arturo López Castel (DC9; [email protected] ), and [email protected] , including your CV, motivation letter, academic certificates, proof of English proficiency, national identity card, and two recommendation letters.
Funding details
Funded through the ENTRY-DM MSCA multidisciplinary doctoral network
How to apply
Submit a single PDF document to specified email addresses
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