PhD in Haemoelasticity and Biomechanics of Abdominal Aortic Aneurysms (AAA) The University of Manchester in United Kingdom

This PhD project at The University of Manchester focuses on the haemoelasticity and biomechanics of abdominal aortic aneurysms (AAA), a critical area in cardiovascular research. The progression and rupture risk of AAAs are determined by the complex interplay between blood flow dynamics and the mechanical properties of the aortic wall. Unlike rigid pipes, the aorta is a compliant, deformable vessel that responds dynamically to pulsatile hemodynamic loads, exhibiting nonlinear elasticity, anisotropy, and viscoelasticity. Localized weakening or geometric irregularities can amplify fluid-structure coupling, leading to abnormal wall strains, vortical blood flow, and regions of elevated rupture risk.

The project aims to develop a comprehensive theoretical and computational framework for analyzing the coupled dynamics of blood flow and aortic wall deformation. Objectives include developing mathematical and computational models to capture these dynamics, quantifying the influence of structural and material properties on stress distribution and rupture risk, and exploring strategies for optimizing medical interventions such as stent graft placement. The research will leverage prior work on patient-specific haemodynamic simulations to provide mechanistic insights into AAA progression, supporting better clinical decision-making and guiding future diagnostic and therapeutic strategies.

Applicants should have, or expect to achieve, at least a 2.1 honours degree or a master’s (or international equivalent) in a relevant science or engineering discipline. A strong background in mathematical modelling, mechanics, or biomedical engineering is highly desirable. English language proficiency is required for non-native speakers. The project is based in the Department of Mechanical and Aerospace Engineering, and the successful candidate will join a vibrant, interdisciplinary research environment.

Funding is available for excellent candidates through competence-based faculty funding, covering tuition fees and providing a tax-free stipend at the UKRI rate (£20,780 for 2025/26), with expected annual increases. Self-funded students are also welcome to apply. The start date is October 2026, and applications are accepted year-round, but early application is recommended as the advert may be removed once the position is filled.

To apply, candidates should contact the supervisor to discuss their background and motivation, then submit an online application specifying the project title and supervisor. Required documents include transcripts, certificates, a CV, a supporting statement, and contact details for two referees. The university values equality, diversity, and inclusion, and encourages applications from candidates of all backgrounds, including those returning from a career break or seeking flexible study arrangements.