This PhD project at The University of Manchester focuses on advancing the extraction and stabilization of membrane proteins using innovative polymer chemistry. Membrane proteins, which constitute 20–30% of all human proteins, are vital for biological processes and drug discovery but are notoriously difficult to study due to their low solubility. The project aims to improve nanodisc-forming polymers, particularly those based on styrene/maleic anhydride (SMALPS), to enhance protein extraction efficiency, speed, and buffer/salt tolerance.

Research will be conducted in the GibsonGroup, located within the Manchester Institute of Biotechnology, which offers state-of-the-art synthetic polymer laboratories (established in 2023), microbiology, and tissue culture facilities. The group provides access to advanced equipment, including automation platforms, benchtop NMR, confocal microscopy, and biolayer interferometry, fostering a collaborative and supportive research environment.

The project integrates modern synthetic polymer chemistry with protein biochemistry, utilizing high-throughput synthesis and characterization tools. Students will develop expertise in polymer design, protein extraction, and analytical techniques, contributing to the development of new materials for biomedical applications.

Eligibility requires at least a 2.1 honours degree or a master’s (or international equivalent) in Chemistry or a closely related discipline. Strong candidates with backgrounds in synthetic chemistry, polymer chemistry, or biochemistry are encouraged to apply. International applicants must meet English language requirements.

Funding is available for excellent candidates through competence-based faculty funding, with application deadlines on 19th December 2025 and, if places remain, 13th March 2026. The university offers a range of scholarships, studentships, and awards for both UK and overseas postgraduate researchers. The PhD duration is 3.5 years, with a start date in October 2026. Flexible study arrangements, including part-time options, may be considered depending on project and funding.

Applicants should contact Professor Matt Gibson by email ([email protected]) with a CV (max 2 pages) detailing research experience and academic grades before applying. Applications are submitted online via the university website, specifying the project title and supervisor. Required documents include transcripts, certificates, CV, supporting statement, and contact details for two referees. Incomplete applications will not be considered.

The University of Manchester is committed to equality, diversity, and inclusion, actively encouraging applicants from all backgrounds and career paths. For further details, visit the GibsonGroup research page and the university’s funding database.