The University of Portsmouth is offering a fully funded PhD position in the Cayuso Lab at the Institute of Life Sciences and Healthcare (ILSH), focusing on CASK-related neurodevelopmental disorders. The project aims to generate and analyse zebrafish models of CASK disorders using advanced CRISPR/Cas9 genome editing, fluorescence imaging, and molecular and cellular approaches. The research will investigate how CASK loss affects brain development and neuronal survival, contributing to the understanding of microcephaly with pontine and cerebellar hypoplasia (MICPCH), a rare disorder caused by CASK gene variations. Supervised by Dr Jordi Cayuso and Professor Matt Guille, the student will receive comprehensive training in zebrafish genetics, neurodevelopmental biology, and quantitative image analysis. The project will combine genetic, cellular, and developmental analyses to uncover mechanisms of neurodevelopmental disorders, focusing on neural and craniofacial defects, neuronal apoptosis, and glial cell function. Collaboration opportunities exist with groups specialising in neural repair, neuroinflammation, and disease modelling, as well as interactions with charities and patient groups. Applicants should have a strong background in Biomedical Science, Neuroscience, Developmental Biology, Genetics, or related disciplines, with a good undergraduate or Master’s degree. Essential skills include interest in neurodevelopmental disorders, cell biology, genetics, organisational ability, teamwork, and willingness to work with zebrafish. Desirable skills include molecular biology techniques, microscopy, image analysis, statistical analysis, and communication skills. English proficiency at IELTS 6.5 (no component below 6.0) is required. The position is fully funded for UK/EU and international students, covering tuition fees for three years, a UKRI-rate stipend (£20,780 for 2025/26), and £1,500 per annum for project costs. Visa and immigration health surcharge costs are not covered. The application deadline is 16 January 2026, with the project commencing in October 2026. Interested candidates should apply online, quoting project code MPB50700126, and prepare all required documents. For project-specific queries, contact Dr Jordi Cayuso by email. This opportunity is ideal for motivated candidates interested in developmental biology, neuroscience, and disease modelling, offering advanced research training and the chance to contribute to impactful research in neurodevelopmental disorders.