KU Leuven’s Department of Cardiovascular Sciences is offering a fully funded 4-year PhD position focused on vascular and lymphatic complications in Fontan circulation. The project aims to advance understanding of complications arising in patients with failing Fontan circulation, a critical procedure for individuals born with a single functional heart chamber. The research will involve analyzing clinical data and lymphatic changes in patients, conducting translational research using a large-scale sheep model, and applying advanced imaging techniques such as MRI, echocardiography, and histology. The successful candidate will collaborate with a multidisciplinary team including experts in pediatric cardiology, cardiac surgery, vascular biology, and lymphatic research. The goal of the project is to develop detailed insights into vascular and lymphatic changes, ultimately improving diagnosis, management, and patient outcomes for those with congenital heart defects. The position offers integration into the European research network, access to state-of-the-art clinical and research facilities, and opportunities for skill development, research innovation, and participation in international conferences. Career support for young international scientists is also provided. Applicants should hold a Master’s degree in Medicine or a related discipline, possess a creative and analytical mindset, and have a strong interest in cardiovascular research, particularly MRI imaging of congenital heart defects. Excellent English communication skills are required, and knowledge of Dutch is a plus. Candidates should be able to work independently and as part of a team, demonstrate flexibility and precision, and be motivated to work with both animal models and patient data. Additional responsibilities include contributing to research proposals and supervising master students. To apply, candidates should submit their application online via the KU Leuven application portal by 30 April 2026. For academic enquiries, contact Prof. Ruth Heying or Prof. Sarah Thomis. This opportunity is ideal for those seeking to advance their career in cardiovascular translational research and make a meaningful impact on clinical outcomes for patients with congenital heart defects.

This PhD position at KU Leuven focuses on research into vascular and lymphatic complications in Fontan circulation, a surgical procedure for individuals born with only one functional heart chamber. The project is based in the Department of Cardiovascular Sciences and is part of an interdisciplinary collaboration involving Pediatric Cardiology, Cardiac and Vascular Surgery, and Molecular and Vascular Biology. The research environment is highly supportive, offering access to advanced laboratory spaces and facilities for both in vivo and ex vivo experimental work. The main aim of the project is to investigate the mechanisms underlying lymphatic and vascular complications in patients with failing Fontan circulation. About one-third of adult Fontan patients experience significant complications, and this research seeks to bridge clinical treatment and translational science. The project utilizes both animal models (including a large-scale sheep model) and patient data to analyze changes in blood and lymphatic vessels that contribute to Fontan failure. Advanced imaging techniques such as MRI, echocardiography, and histological evaluations will be applied to assess hemodynamic and lymphatic changes. This translational approach is designed to provide innovative and detailed lymphatic assessments, ultimately improving the understanding and management of Fontan patients. The successful candidate will work closely with a multidisciplinary team, including experts in cardiac surgery, pediatric cardiology, vascular biology, and lymphatic research. The project offers opportunities to develop expertise in clinical and translational research, access to clinical treatment and advanced imaging facilities, and integration into the European research landscape. There are also possibilities to attend international conferences and build research and innovation skills. Applicants should have a master's degree in medicine or a related discipline, a creative and analytical mindset, and a strong interest in cardiovascular research, especially MRI imaging in congenital heart defects. Excellent communication skills in English are required, with Dutch proficiency considered an asset. Candidates must be able to work independently and as part of a team, demonstrate flexibility and precision, and be motivated to contribute to a multidisciplinary research environment. Responsibilities include working with animal models and patient data, contributing to research proposal writing, and supervising master students. Funding is secured for four years, and KU Leuven provides a stimulating environment for international students and young scientists. The institution is committed to diversity, inclusion, and equal opportunity, offering support for accessibility and career development. For more information, applicants can contact Prof. Ruth Heying or Prof. Sarah Thomis by email. The application deadline is April 30, 2026. Apply online via the KU Leuven jobsite using the provided application link. Ensure your application is submitted before the deadline and prepare all necessary supporting documents.