James Spencer
Top university
5 months ago
Overcoming ß-lactamase-mediated antibiotic resistance University of Bristol in United Kingdom
Degree Level
PhD
Field of study
Molecular Biology
Funding
This is a fully funded 4-year PhD position through the GW4 BioMed Doctoral Training Programme. Funding covers tuition fees and provides a stipend for living expenses. The position is not self-funded and includes support for research activities.
Deadline
Expired
Country
United Kingdom
University
University of Bristol
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Where to contact
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About this position
Details:
*Overcoming ß-lactamase-mediated antibiotic resistance by combining biomolecular simulation and experiment*
GW4 Biomed Doctoral Training Programme 4 year PhD project
Co-supervisors: James Spencer , Catherine Tooke , Adrian Mulholland
Antibiotic resistance threatens human health. ß-lactamases cause resistance to ß-lactams, the most widely used antibiotics. Class C ß-lactamases are not well understood, but variants are emerging that help bacteria evade even ‘last resort’ treatments. By combining computer simulation (molecular dynamics, reaction simulations) and experimental methods (enzyme assays, crystallography) you will study how, finding links between structure and activity. This will help to regain the upper hand in the ‘biochemical warfare’ between humans and bacteria. The focus will be on the use of multiscale (QM/MM and ML/MM) reaction simulations.
Related publication: A. H. Lima, M. W. van der Kamp, 2025. Insights into the Enhanced Ceftazidime Hydrolysis by Ent385 AmpC ß-Lactamase from Multiscale Simulations. ACS Catal., 15, 11739–11748, DOI: 10.1021/acscatal.5c02383.
More information on project and DTP:
https://lnkd.in/e7ZC3wFR
Applications close Oct 20th, but please contact me before applying to the DTP (by October 5th), with a draft for the text fields on the application form.
Funding details
This is a fully funded 4-year PhD position through the GW4 BioMed Doctoral Training Programme. Funding covers tuition fees and provides a stipend for living expenses. The position is not self-funded and includes support for research activities.
What's required
Applicants must have a strong background in microbiology or a related biological science. Experience or interest in computational biology, molecular dynamics, enzyme assays, or structural biology is desirable. Selection is highly competitive and managed by the GW4 BioMed DTP. Candidates should prepare a draft for the application form text fields and contact the lead supervisor before applying. No specific GPA or language requirements are mentioned, but standard PhD entry requirements for UK universities apply.
How to apply
Contact Marc van der Kamp by October 5th with a draft of your application text fields. Then apply through the GW4 BioMed DTP by October 20th. Review project details at the provided link and follow DTP application instructions.
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