Aston University
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PhD in Investigating the Role of Oxysterols in Cholesterol Metabolism and Myelin Maintenance Aston University in United Kingdom
Degree Level
PhD
Field of study
Inflammation
Funding
Funded PhD Project (Students Worldwide)
Deadline
Year round applications
Country
United Kingdom
University
Aston University
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Where to contact
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About this position
This PhD project at Aston University investigates the complex interplay between oxysterols, cholesterol metabolism, and myelin maintenance in the central nervous system. Cholesterol is essential for cellular structure and function, particularly as a key component of myelin, which insulates nerve fibres and supports efficient nerve conduction and brain function. When cholesterol is oxidized, it forms oxysterols—bioactive molecules that can influence lipid homeostasis, inflammation, and cell signalling, with both protective and detrimental effects on myelin depending on their structure and concentration.
The research will utilize in vitro cell culture models and advanced mass spectrometry techniques to profile cholesterol and oxysterol pathways. By examining oxysterol levels in the context of neurological diseases such as multiple sclerosis, the project aims to elucidate how altered cholesterol metabolism and myelin degeneration contribute to disease progression. The ultimate goal is to advance understanding of oxysterols in myelin biology and inform the development of new therapeutic approaches for demyelinating disorders.
The position is based at Aston University's College of Health and Life Sciences in Birmingham, UK. Applicants should be able to attend campus regularly. The project is open to both Home and Overseas applicants; however, only Home tuition fees are covered, and Overseas students must pay the difference (£17,712 for 2026/7). Candidates must have a strong academic background in a relevant subject, with specific degree requirements outlined below. Applications must include all supporting documents, including transcripts, research and personal statements, CV, references, and evidence of English language proficiency. Interviews will be conducted online for shortlisted candidates.
For further information, contact Dr Irundika Dias at [email protected]. Apply online via the provided link, selecting 'Research - Health Sciences' on the application form. For application process queries, contact [email protected].
Funding details
Funded PhD Project (Students Worldwide)
What's required
Applicants must have, or expect to achieve, either a First or Upper Second Class undergraduate degree (Bachelors or UG Masters) from a UK institution in a relevant subject, or a Merit (or above) in a relevant Postgraduate Masters degree plus an undergraduate degree, both from UK institutions. Overseas qualifications will be considered if equivalent. Applicants must provide English language transcripts and certificates for all higher education degrees, a research statement, personal statement, CV, two academic references (at least one from the most recent university), evidence of English language proficiency (can be submitted later), and a copy of their passport. Overseas applicants must confirm ability to pay the tuition fee difference.
How to apply
Apply online via the provided link, selecting 'Research - Health Sciences' on the application form. Ensure all supporting documents are included, as incomplete applications will be rejected. Shortlisted candidates will be invited for an online interview via Microsoft Teams. For questions, contact the Postgraduate Admissions team at [email protected].
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