The Max Planck Institute for Heart and Lung Research in Bad Nauheim, Germany, is offering a PhD position in RNA/protein biochemistry and molecular biology, focusing on the study of genetic compensation and transcriptional adaptation. The research is based in the Department of Developmental Genetics (Stainier lab) and investigates the molecular and cellular mechanisms underlying cardiovascular and pulmonary diseases. The project centers on the phenomenon of transcriptional adaptation, where mutant mRNA decay fragments modulate the expression of related genes, leading to phenotypic rescue. This research utilizes model organisms such as zebrafish, mouse, C. elegans, and humans, and leverages cutting-edge technologies and core facilities in sequencing, proteomics, bioinformatics, cytometry, microscopy, and small animal imaging.

Applicants should have a Master's degree in biology, biochemistry, genetics, or a related field, with a strong background in molecular biology and RNA/protein biochemistry. Experience with zebrafish, mouse, or C. elegans is advantageous. The institute values diversity and encourages applications from all backgrounds, including individuals with disabilities. The position provides an interdisciplinary and international research environment, with access to state-of-the-art facilities and support for young researchers.

To apply, candidates should submit a CV, names and contact information for 2-3 references, and a short statement of research experience and interests to Prof. Didier Stainier at [email protected]. Additionally, applications should be submitted to the International Max Planck Research School for Molecular Organ Biology (IMPRS-MOB). For more information, visit the provided website links.

Key research areas include genetic compensation, transcriptional adaptation, RNA and protein biochemistry, molecular biology, developmental genetics, and gene expression. The position is ideal for candidates passionate about genetic research and eager to contribute to a rapidly developing field with significant implications for understanding disease mechanisms.