Postdoc in Neurodegeneration & Patient Specific iPSC Organoids University of Luxembourg in Luxembourg

The University of Luxembourg, a leading international research university, is offering a postdoctoral position at the Luxembourg Centre for Systems Biomedicine (LCSB). The LCSB is renowned for its interdisciplinary research in Systems Biology and Biomedicine, with a strong focus on neurodegenerative diseases such as Alzheimer's and Parkinson's. The centre brings together scientists from diverse backgrounds, fostering a collaborative environment that advances both fundamental and translational research.

This postdoctoral opportunity centers on investigating the mechanisms of Parkinson's disease using patient-specific iPSC-derived midbrain organoids, assembloids, and chimeroids. The project emphasizes high-throughput technologies and protein aggregation analysis, integrating stem cell biology, stress granule biology, multi-omics, and therapeutic target validation. Key responsibilities include generating, maintaining, and differentiating human iPSCs, designing and executing stress paradigms, performing high-content imaging and confocal microscopy, functional phenotyping with HD-MEA electrophysiology, testing therapeutic strategies, and coordinating single-cell RNA-seq and proteomics workflows. The role also involves supervision and mentoring of PhD students and technical staff, manuscript preparation, and active participation in an international consortium.

Applicants must possess a PhD in neuroscience, stem cell biology, neurobiology, or a related field, with strong experience in human iPSC culture and neural differentiation. A solid background in cell biology, neurodegeneration, or RNA biology is essential. Candidates should be capable of working independently, supervising team members, and managing complex projects. Desirable skills include experience with organoids or assembloids, familiarity with omics approaches (scRNA-seq, proteomics), programming or data analysis skills (R, Python), experience in international collaborative projects, and laboratory automation.

The University of Luxembourg offers a modern, dynamic, and multilingual environment, with staff from over 90 countries and close ties to industry and European institutions. The position is based at the Belval Campus and is a fixed-term contract for 24 months, full-time (40 hours per week). The yearly gross salary for postdoctoral researchers is EUR 85176. The institution promotes an inclusive culture and encourages applications from individuals of all backgrounds.

To apply, candidates should submit their application online via the University of Luxembourg HR system, including a curriculum vitae and cover letter. Early applications are encouraged as review begins upon receipt. Applications by email will not be considered. For further details and to access the application portal, visit the provided link.