Karin Lindkvist
Top university
1 year ago
Systemic Inflammatory Response Syndrome (SIRS) and AQP9 inhibition Lund University in Sweden
Degree Level
PhD
Field of study
Cell Biology
Deadline
Expired
Country
Sweden
University
Lund University
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Where to contact
Official Email
Keywords
Cell Biology
Immunology
Biochemistry
Molecular Biology
Biotechnology
Biology
Drug Discovery
Structural Biology
Protein Biochemistry
Cryo-em
Immune Response
About this position
How to apply
Apply by email to Prof. Karin Lindkvist ([email protected])
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We are looking for outstanding graduates from all over the world and are delighted to provide them with the best possible conditions for their scientific careers. The graduate program Lund University at faculty of medicine provides an interdisciplinary education for doctoral candidates at the interface of molecular life sciences and clinical science. In addition, the candidate will be employed and strongly connected to the scientific activities at a small biotech company Apoglyx AB. If you have a passion for structural biology, molecular biology, cell biology, protein biochemistry and drug discovery and want to work in an interdisciplinary setting at Lund University at faculty of medicine- this is the doctoral program for you!
Application:
Please prepare your CV and motivation letter, your academic record and the name of two referees willing to provide references, then apply by the 1st of January 2025 by email to: Prof. Karin Lindkvist ( [email protected] )
Short summary of the project with a few references from Lindkvist laboratory.
Maintaining a balance between activation and suppression of immune response is critical for the immune system. Systemic Inflammatory Response Syndrome (SIRS) is an exaggerated response of the immune system and is a potentially life-threatening medical condition that is characterized by a self-harming immune response. SIRS can be initiated by an infection (then called sepsis), or by sterile causes of cell damage, such as trauma. A hallmark of both sepsis and SIRS is the massive recruitment neutrophils from the bone marrow into the circulation. Together with academic collaborators, ApoGlyx AB has demonstrated that genetic ablation of AQP9 is an effective way for interfering with SIRS, by preventing tissue infiltration of neutrophils. Based on these promising results, the aim is to decipher the structural-functional activity of AQP9 and develop a series of compounds blocking its activity. The 3D structure of AQP9 will be determined with and without inhibitors by single particle cryo-EM to augment structure-based drug design. Furthermore, the inhibitor-effect of the newly developed compounds will be evaluated in neutrophils.
Molecular basis for human aquaporin inhibition.
Huang P, Åbacka H, Wilson CJ, Wind ML, Rützler M, Hagström-Andersson A, Gourdon P, de Groot BL, Venskutonyte R, Lindkvist-Petersson K.
Proc Natl Acad Sci U S A. 2024 Feb 13;121(7):e2319682121.
SMS121, a new inhibitor of CD36, impairs fatty acid uptake and viability of acute myeloid leukemia
Åbacka H, Masoni S, Poli G, Huang P, Gusso F, Granchi C, Minutolo F, Tuccinardi T, Hagström-Andersson AK, Lindkvist-Petersson K.
Sci Rep. 2024 Apr 20;14(1):9104.
Cryo-EM structure supports a role of AQP7 as a junction protein.
Huang P, Venskutonyte R Prasad RB, Ardalani H, de Maré SW, Fan X, Li P, Spégel P, Yan N, Gourdon P, Artner I, Lindkvist-Petersson K.
Nature Commun. 2023 Feb 3;14(1):600.