Manchester-Melbourne Dual Award: Elucidating the Mechanisms of Immune Cells-Fibroblasts Coordination in Producing a Collagen-Rich Tissue

This Manchester-Melbourne Dual Award PhD project offers a unique opportunity to investigate the molecular mechanisms underlying the coordination between immune cells and fibroblasts in the production of collagen-rich tissues. Collagen, the most abundant protein in the human body, is essential for the structural integrity of organs and tissues, with its deposition tightly regulated to prevent pathologies such as fibrosis, heart disease, tissue degeneration, and poor wound healing. Despite its importance, there is a significant gap in our understanding of how different cell types interact to assemble and remodel collagen within three-dimensional tissue environments. Based at The University of Manchester, with a 12-month research period at The University of Melbourne, you will be part of the Global Doctoral Research Network (GOLDEN) and registered at both institutions. The project employs advanced techniques including proteomics, genome editing, biochemical assays, biomaterials, and imaging to dissect the molecular control of collagen fibrillogenesis. You will explore how fibroblasts and immune cells coordinate through cell-cell interactions and autocrine/paracrine signaling to regulate collagen deposition, with a particular focus on fibrotic responses and the identification of new therapeutic targets for lung fibrosis. The Division of Molecular and Cellular Function at Manchester provides a vibrant research environment, and the dual-award structure ensures international collaboration and training. The studentship is fully funded, covering tuition fees, a tax-free stipend at the UKRI rate for 3.5 years, return travel to Melbourne, health insurance, and additional support for research and training. The programme starts in September 2026. Eligibility requires a First or Upper Second class (2:1) UK honours degree or international equivalent in a relevant subject. Applicants must submit a complete application including CV, supporting statement, academic certificates, and transcripts. Incomplete or late applications will not be considered. Candidates are required to contact the primary supervisor prior to applying to discuss their interest and suitability for the project. Applications are submitted via the online portal, selecting PhD Molecular Biology as the programme of study. You may apply for up to two projects within this scheme by listing both project titles and supervisor names in a single application. The deadline for applications is Friday, March 13, 2026. For further details, visit the project webpage.