This fully funded PhD position at the University of Bristol, offered through the SWBio DTP, investigates the mechanisms of neuroinflammation and dopaminergic modulation in brain injury, with a particular focus on astrocyte reactivity. Neuroinflammation is a natural response to nervous system threats, but when excessive, it can become chronic and contribute to neurodegenerative diseases such as Alzheimer's, Parkinson's, and persistent symptoms following traumatic brain injury (TBI). Despite the prevalence of brain injury and its impact on health, the underlying disease progression mechanisms remain poorly understood. This project employs an interdisciplinary approach, combining in vivo studies using Drosophila flies and in vitro experiments with human induced pluripotent stem cell (iPSC)-derived astrocytes. The research aims to elucidate how astrocytes respond to inflammatory signals, produce cytokines, and exhibit phagocytic activity in both insect and human models. The objectives include evaluating damage in dopaminergic circuits post-injury using advanced imaging and physiological analysis, characterizing injury-induced inflammatory mechanisms by assessing astrocyte activity and dopamine receptor expression, and determining whether dopamine manipulation can modulate neuropathology after brain injury. Techniques such as optogenetics will be used to manipulate dopaminergic neurons in flies, while human cell models will be used to study astrocyte reactivation under inflammatory conditions and dopamine modulation. The SWBio DTP provides a supportive and inclusive environment, accommodating flexible working, part-time study, and reasonable project adaptations for students with diverse backgrounds and circumstances. The studentship covers a four-year period, including a competitive stipend, full tuition, research costs, and additional funds for fieldwork, conferences, and placements. Applicants should have a strong academic background in neuroscience, biology, or related fields, and meet the University of Bristol's English language requirements. The application deadline is December 3, 2025, and further details on the programme and application process are available on the SWBio DTP website.