Tatu Pantsar at University of Eastern Finland - Research Interests, Publications & Academic Profile

Tatu Pantsar

University of Eastern Finland

Finland

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Research Interests

Biochemistry

30%

Pharmaceutical Chemistry

70%

Chemical Biology

60%

Ligand Design

50%

Kinase Biology

40%

Drug Metabolism

20%

Macrocyclic Chemistry

20%

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Articles11

In Silico Evaluation of the Thr58-Associated Conserved Water with KRAS Switch-II Pocket Binders

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Year:

2023

Target Hopping from Protein Kinases to PXR: Identification of Small-Molecule Protein Kinase Inhibitors as Selective Modulators of Pregnane X Receptor from TüKIC Library

Article Link

Year:

2022

Decisive role of water and protein dynamics in residence time of p38α MAP kinase inhibitors

Article Link

Year:

2022

Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors

Article Link

Year:

2021

Identification and characterization of novel splice variants of human farnesoid X receptor

Article Link

Year:

2021

Molecular Dynamics Simulations in Drug Discovery and Pharmaceutical Development

Article Link

Year:

2020

Discovery and Evaluation of Enantiopure 9H-pyrimido[4,5-b]indoles as Nanomolar GSK-3β Inhibitors with Improved Metabolic Stability.

Article Link

Year:

2020

Design and synthesis of novel fluorescently labeled analogs of vemurafenib targeting MKK4.

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Year:

2020

The autoinhibited state of MKK4: Phosphorylation, putative dimerization and R134W mutant studied by molecular dynamics simulations.

Article Link

Year:

2020

KRAS(G12C)-AMG 510 interaction dynamics revealed by all-atom molecular dynamics simulations.

Article Link

Year:

2020

Bioisosteric Replacement of Arylamide-Linked Spine Residues with N-Acylhydrazones and Selenophenes as a Design Strategy to Novel Dibenzosuberone Derivatives as Type I 1/2 p38α MAP Kinase Inhibitors.

Article Link

Year:

2020

Collaborators2

Atefeh Saadabadi

Åbo Akademi University

FINLAND

Eveline Lescrinier

Professor

KU Leuven

BELGIUM

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Tatu Pantsar

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Research Interests

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Articles11

In Silico Evaluation of the Thr58-Associated Conserved Water with KRAS Switch-II Pocket Binders

Target Hopping from Protein Kinases to PXR: Identification of Small-Molecule Protein Kinase Inhibitors as Selective Modulators of Pregnane X Receptor from T&uuml;KIC Library

Decisive role of water and protein dynamics in residence time of p38α MAP kinase inhibitors

Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors

Identification and characterization of novel splice variants of human farnesoid X receptor

Molecular Dynamics Simulations in Drug Discovery and Pharmaceutical Development

Discovery and Evaluation of Enantiopure 9H-pyrimido[4,5-b]indoles as Nanomolar GSK-3β Inhibitors with Improved Metabolic Stability.

Design and synthesis of novel fluorescently labeled analogs of vemurafenib targeting MKK4.

The autoinhibited state of MKK4: Phosphorylation, putative dimerization and R134W mutant studied by molecular dynamics simulations.

KRAS(G12C)-AMG 510 interaction dynamics revealed by all-atom molecular dynamics simulations.

Bioisosteric Replacement of Arylamide-Linked Spine Residues with N-Acylhydrazones and Selenophenes as a Design Strategy to Novel Dibenzosuberone Derivatives as Type I 1/2 p38α MAP Kinase Inhibitors.

Collaborators2

Atefeh Saadabadi

Eveline Lescrinier

How do Indian students reach out?

Target Hopping from Protein Kinases to PXR: Identification of Small-Molecule Protein Kinase Inhibitors as Selective Modulators of Pregnane X Receptor from TüKIC Library