Xiumei Huang at Indiana University School of Medicine - Research Interests, Publications & Academic Profile

Xiumei Huang

Assistant Professor

Indiana University School of Medicine

United States

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Research Interests

Cell Biology

20%

Biochemistry

40%

Dna Damage

40%

Cancer Biology

30%

Cancer Therapy

20%

Cytotoxicity

20%

Oxidative Stress

10%

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Recent Grants

Grant: Close

Targeting NQO1+ tumor to trigger innate and adaptive immunity

Open Date: 2020-07-01

Close Date: 2025-06-01

Grant: Close

Tumor-selective use of PARP inhibitors against NQO+ non-small cell lung cancer

Open Date: 2020-03-01

Close Date: 2022-11-01

Grant: Close

Tumor-selective radiosensitization of NSCLC using NQO1 bioactivatable drugs

Open Date: 2020-02-01

Close Date: 2022-12-01

Articles10

Critical Role of Novel O-GlcNAcylation of S550 and S551 on the p65 Subunit of NF-κB in Pancreatic Cancer

Article Link

Year:

2023

Augmented Concentration of Isopentyl-Deoxynyboquinone in Tumors Selectively Kills NAD(P)H Quinone Oxidoreductase 1-Positive Cancer Cells through Programmed Necrotic and Apoptotic Mechanisms

Article Link

Year:

2023

IP-DNQ induces mitochondrial dysfunction and G2/M phase cell cycle arrest to selectively kill NQO1-positive pancreatic cancer cells.

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Year:

2023

Synergistic Effect of β-Lapachone and Aminooxyacetic Acid on Central Metabolism in Breast Cancer

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Year:

2022

KP372-1-Induced AKT Hyperactivation Blocks DNA Repair to Synergize With PARP Inhibitor Rucaparib via Inhibiting FOXO3a/GADD45α Pathway.

Article Link

Year:

2022

Neutrophils: Musketeers against immunotherapy.

Article Link

Year:

2022

Inhibition of PRMT5 by market drugs as a novel cancer therapeutic avenue

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Year:

2022

β-Lapachone Selectively Kills Hepatocellular Carcinoma Cells by Targeting NQO1 to Induce Extensive DNA Damage and PARP1 Hyperactivation.

Article Link

Year:

2021

PCNA inhibition enhances the cytotoxicity of β-lapachone in NQO1-Positive cancer cells by augmentation of oxidative stress-induced DNA damage.

Article Link

Year:

2021

Targeting Base Excision Repair in Cancer: NQO1-Bioactivatable Drugs Improve Tumor Selectivity and Reduce Treatment Toxicity Through Radiosensitization of Human Cancer

Article Link

Year:

2020

Collaborators4

Naveen Singh

Asst. Professor (Tenure Track)

New Mexico Highlands University

UNITED STATES

Matthew Merritt

Associate Professor

University of Florida

UNITED STATES

Edward Motea

Assistant Professor

Indiana University School of Medicine

UNITED STATES

Tao Lu

Indiana University School of Medicine

UNITED STATES

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