Our laboratory focuses on studying epigenetic influences on evolutionary processes in high-grade gliomas at multiple levels. We will use a combination of primary patient-derived high-grade glioma cell culture models, patient tissues, and human neural stem-cell based models alongside functional techniques to improve our understanding of state plasticity in this disease. This project will rely on a combination of functional glioma stem cell and epigenetics techniques alongside next-generation sequencing (including single-cell sequencing) and their subsequent analysis. The successful applicant will have an opportunity to train in a number of cancer stem cell, imaging and epigenetics techniques and will be encouraged to learn and improve their bioinformatics and data analytics skills, including a strong emphasis on learning R and/or Python during their training. This project is fully funded by the University of Calgary.

Applicant Requirements:

The successful candidate should have the following:

-      MSc in a relevant field (biochemistry, cancer biology, epigenetics, neuroscience bioinformatics) or B.Sc. with GPA of 3.6 or higher (UK: upper second class BSc or higher)

-      Strong proficiency in written and spoken English

-      Prior experience in a laboratory environment (familiarity with common techniques such as PCR, Western blot, immunohistochemistry; cell culture experience) would be ideal

-      Bioinformatics or programming experience would be an asset (especially R or Python)

-      Background in neuroscience would be an asset

-      Capacity for self-directed learning and independence

Location:

The lab is situated within the Charbonneau Cancer Institute ( https://charbonneau.ucalgary.ca/ ), within the Foothills Medical Center at the University of Calgary in Calgary, Alberta, Canada. Calgary is a busy, large city of nearly 1.5 million people, with a diverse population and many activities. Situated in the foothills of the Rocky Mountains, Calgary is less than an hour’s drive away from world-class scenery and some of the best skiing, hiking, snowboarding and rock climbing in North America.

Funding Requirements:

This project is fully funded and students will be encouraged to apply for scholarships as appropriate. It is open to citizens of Canada, USA, UK, Australia, New Zealand, and the European Union.

To apply:

Please send cover letter and updated CV to Dr. Ana Nikolic (see contact information above).