Spinal Cord Injury Treatment with Immunomodulatory Exosomes and Second Generation PI3Kdelta Gene Therapy Institute of Experimental Medicine of the Czech Academy of Sciences in Czech Republic

This PhD position at the Institute of Experimental Medicine of the Czech Academy of Sciences offers an exciting opportunity to contribute to cutting-edge research in the treatment of spinal cord injury (SCI). The project focuses on developing complex therapeutic strategies, combining immunomodulatory exosomes and second generation PI3Kdelta gene therapy to address the multifaceted pathology of SCI. Students will engage in advanced cell biology and neuroscience research, exploring molecular and cellular mechanisms underlying neuroinflammation, neuroprotection, and regeneration in the central nervous system.

Under the supervision of Dr KK Kárová, candidates will work within a dynamic research department, utilizing state-of-the-art laboratory techniques and collaborating with experts in the field. The project aims to advance understanding of SCI and develop innovative therapeutic approaches that could have significant clinical impact. Research activities may include exosome isolation and characterization, gene therapy vector design, in vitro and in vivo models of SCI, and analysis of neurobiological outcomes.

Applicants should possess a strong background in biology, neuroscience, or medical science, with experience in cell biology, molecular biology, or neurobiology considered advantageous. The position requires motivation for research, proficiency in English, and the ability to work both independently and as part of a team. While funding details are not specified, the Institute provides a stimulating academic environment and access to modern research facilities.

The application deadline is 31 March 2026. Prospective students are encouraged to review the project details and prepare their application materials, including a CV, cover letter, and academic transcripts. For further information, candidates may contact the supervisor or visit the provided project link. This opportunity is ideal for those seeking to advance their expertise in neuroscience and contribute to impactful translational research in SCI treatment.