PhD in Molecular Biology: The Role of Long Non-coding RNAs in Guard Cell Function and Development (BBSRC Yorkshire Bioscience DLA Programme)

This fully funded PhD position at the University of Sheffield, offered through the BBSRC Yorkshire Bioscience Doctoral Training Partnership (YBDTP), focuses on the molecular role of long non-coding RNAs (IncRNAs) in plant guard cell function and development. The project is led by Dr Stuart Casson, Dr Dan Bose, and Prof Julie Gray, whose labs have identified IncRNAs highly expressed in guard cells—cells that regulate gas exchange in plants. At least one of these IncRNAs is crucial for plant responses to increased carbon dioxide, and the research aims to translate this knowledge to improve crop resilience to abiotic stress. The successful candidate will investigate how these IncRNAs regulate plant responses to various abiotic signals, including CO2, light, humidity, and plant hormones. The project involves using genetic methods such as mutants and transgenics to manipulate IncRNA expression, followed by analysis of plant responses. Advanced molecular techniques, gene expression analysis, chromatin modification studies, and plant physiological assays will be employed to understand the mechanisms by which IncRNAs influence plant abiotic responses. The YBDTP provides a vibrant, interdisciplinary training environment across several Yorkshire and Teesside universities, with opportunities for collaboration, professional development, and international conference participation. Applicants should have a strong background in molecular biology or genetics and an interest in cell signalling and plant-environment interactions. The studentship is open to UK, EU, and international students, with a competitive selection process and limited full studentships for exceptional international candidates. The award covers a four-year UKRI stipend, research costs, and tuition fees at the UK rate. International students must cover their own visa, NHS surcharge, and travel costs. The application deadline is 7 January 2026, and shortlisted candidates will be interviewed in February 2025. For more information or to apply, visit the YBDTP website or contact the supervisors directly.