Bioactive chemical space in pathogenic bacteria

The Francis Crick Institute in London is offering multiple fully funded PhD positions focused on combating antimicrobial resistance through interdisciplinary research. Projects are available in areas such as chemical biology, computational chemistry, microbiology, and drug discovery, with opportunities to work on charting and curating bioactive chemical space in pathogenic bacteria. Supervisors include Eachan Johnson (Crick), Jeannine Hess (Crick/King’s College London), and Marc Lipman (UCL), providing a collaborative environment across leading UK institutions. The research aims to accelerate antibiotic discovery by integrating chemical genomics, molecular genetics, computation, and high-throughput screening. Candidates will develop skills in biophysical techniques, bacterial genetics, infection biology, machine learning, and more. Applicants should have a relevant background in biology, chemistry, or computational sciences, with some wet-lab experience preferred. The programme is open to international students and offers comprehensive training, career development, and support. Application deadlines are 5 November and 14 November, with more information and application links available on the Crick website.