Image-based bacterial phenotyping and antimicrobial drug discovery using smart high-throughput super-resolution microscopy

This fully funded PhD opportunity at the University of Warwick addresses the urgent challenge of antimicrobial resistance through innovative image-based bacterial phenotyping and drug discovery. The project is part of Warwick’s MRC-funded Doctoral Training Partnership (MRC DTP), offering a unique four-year studentship that combines a one-year MSc in Interdisciplinary Biomedical Research with a three-year PhD project. The research is co-supervised by Professor Séamus Holden (School of Life Sciences) and Dr Sam Swift (Cairn Research Ltd UK), providing both academic and industry perspectives. During the MSc year, students will undertake taught modules such as Frontier Techniques in Biomedical Research, Physical Biology of the Cell, Microscopy and Imaging, Mathematical Modelling, and Mass Spectrometry, alongside two laboratory-based research projects. The subsequent PhD phase focuses on developing and applying smart high-throughput super-resolution microscopy tools, including the integration of an open-source 96-well plate loader with the new RAPTOR microscope. The project leverages deep learning analysis to identify novel cell division proteins in Bacillus subtilis and to screen drug libraries for antimicrobial activity against Escherichia coli and Pseudomonas aeruginosa . This interdisciplinary project is ideal for candidates with backgrounds in physics, engineering, computer science, biology, biomedicine, microbiology, biochemistry, or biomedical science, especially those interested in quantitative biology and engineering. The successful candidate will join a vibrant DTP community, benefiting from advanced workshops, transferable skills training, career support, cohort learning events, and conferences with approximately 50 other students. The programme is committed to fostering a supportive and inclusive environment, promoting equality, and challenging discrimination. Applications from minoritized groups under-represented in academia are strongly encouraged. Students receive outstanding mentoring, career guidance, and pastoral support throughout the programme. Funding covers full tuition fees, consumables, conference attendance, and an annual stipend of £24,333 for 2026/27. Additional funding is available for advanced training workshops, international or industry placements, internships, and career transition support. Entry requirements include an excellent undergraduate degree (2:1 or above) in biological, physical, or computational sciences, with advanced skills in mathematics, statistics, physics, or computer science (A-Level or international equivalent). The programme is open to both home and international students. Applications must be submitted by 12:00 noon on March 2, 2026, with interviews scheduled for the week commencing April 13, 2026. For further information, prospective applicants are encouraged to contact Professor Séamus Holden or Dr Sam Swift via email. For full details and to apply, visit the project page: FindAPhD Project Link .