The University of Gothenburg invites applications for a PhD position in Natural Science, specializing in Chemistry with a focus on nanoanalytical chemistry methods to dissect organelles. The position is based in the Department of Chemistry and Molecular Biology, a vibrant research environment covering a wide range of scientific fields from atomic and molecular levels to intact organisms. The Ewing group, led by Professor Andrew Ewing, is funded to investigate chemical communication between organelles at the molecular level, utilizing advanced techniques to measure the chemical contents of single vesicles, exosomes, and reactive oxygen species in stress granules.

This doctoral project centers on developing innovative methods to chemically dissect vesicles and employ fluorescent nanoprobes for measurements at specific individual organelles. Techniques will likely include the development of electrochemical probes, STED super-resolution microscopy, NanoSIMS mass spectrometry imaging, and new single cell approaches. The student will gain expertise in electrochemical nanochemistry analysis, including fabrication and characterization of nanotip and nanopore electrodes, and will use these tools to measure the contents of single vesicles and subvesicular compartments. Cross-referencing with STED microscopy and NanoSIMS imaging will enable dynamic and static quantification of transmitter cargo in vesicles, correlating these findings to interactions between vesicles and other organelles.

The PhD program is a four-year, full-time fixed-term employment, with departmental duties (such as teaching or administration) potentially extending the study period. The University of Gothenburg offers a stimulating international environment, with strong research and attractive study programs. The department requires physical presence for laboratory work, and international applicants must secure a valid residence permit before starting.

Eligibility criteria include a second-cycle (advanced-level) degree in a relevant natural science subject, or equivalent qualifications, and proficiency in English (minimum TOEFL scores specified). Applicants should have a BS and MS in chemistry, chemical technology, or biotechnology, with experience in analytical chemistry method development for single cell or organelle analysis. Skills in electrochemical sensors, mass spectrometry, and fluorescence microscopy are advantageous. Selection is based on academic qualifications, recommendations, expertise, and interview performance, including motivation and leadership skills.

Funding is provided through doctoral student employment, with salary and benefits set individually according to university agreements. The position is open to international applicants, and the university offers support for relocation and integration into Gothenburg. Applications must be submitted online, including a personal letter, CV, diploma and transcripts, proof of English proficiency, and two references. The deadline for applications is March 4, 2026.

For further information, contact Professor Andrew Ewing at [email protected]. Additional details about the division and doctoral studies at the University of Gothenburg can be found on the university's website.