Decoding the Mechanisms of PIN1 in Cancer

This fully funded PhD project at the University of Birmingham, within the Department of Cancer and Genomic Sciences, focuses on decoding the molecular mechanisms of the enzyme PIN1 in cancer. PIN1 is a pivotal regulator of DNA repair, cell growth, and stress responses, and its malfunction is implicated in cancer and other major diseases. Despite promising results from new PIN1 inhibitors in preclinical models, the precise molecular workings of PIN1 remain unclear. The research will investigate how PIN1’s two domains interact with different protein partners and how post-translational modifications control its function. You will receive comprehensive training in advanced techniques such as chemical biology, proteomics, and cancer cell biology, equipping you with skills highly relevant to both academic and pharmaceutical research. The project is supervised by Prof JR Morris, Dr RD Doveston, and Prof G Middleton, who are leading experts in cancer biology and molecular mechanisms. The findings from this research will contribute to a deeper understanding of PIN1 biology and support the development of new therapeutic strategies for cancer treatment. The Medical Research Council studentship provides full funding for four years, covering a generous stipend, tuition fees at both home and international rates, a laptop allowance, research training and support grant (RTSG), and travel allowance. Applications are welcomed from home, EU, and international candidates, though international recruitment is capped at 30% of the cohort due to funding stipulations. Applicants should have or expect to obtain a degree in biological sciences, chemistry, or a related field. The application deadline is midday (GMT) on 9 January 2026, and late applications will not be considered. For further information and to access the application form, please visit the MRC AIM website.