[A tax-free annual stipend at the standard UKRI rate (£20,780 for 2025/26 entry), research costs and tuition fees at UK rate. Limited number of full studentships available for exceptional international applicants.] PhD Studentship – Understanding ESCRT-Mediated Proteostasis Pathways for Neurodegenerative Disease Intervention The University of Bradford, in collaboration with the University of Sheffield, invites applications for a fully funded PhD studentship focused on the molecular mechanisms of ESCRT-mediated proteostasis in neurodegenerative diseases. Neurodegenerative disorders such as Alzheimer’s, Parkinson’s, and motor neuron disease affect millions globally, with limited therapeutic options. The ESCRT system is a key player in the clearance of protein aggregates, exosome biogenesis, and autophagy—processes that are disrupted in these diseases. This interdisciplinary project aims to dissect the molecular mechanisms that govern ESCRT-dependent aggregate clearance versus extracellular vesicle (EV) release. By understanding these pathways, the research seeks to identify novel therapeutic targets for neurodegenerative disease intervention. The successful candidate will gain hands-on experience with advanced molecular and cellular biology techniques, manipulation of neuronal cell models using genetic (lentiviruses) and pharmacological tools, work with patient-derived stem cells, and utilize state-of-the-art microscopy. The studentship is part of the BBSRC Yorkshire Bioscience Doctoral Training Partnership (YBDTP), which brings together leading bioscience research and doctoral supervision across the Yorkshire and Teesside region. The YBDTP offers a regional doctoral training programme with interdisciplinary collaboration at its core, equipping students with research and professional skills for both academic and non-academic bioscience careers. Funding: The studentship provides a tax-free annual stipend at the standard UKRI rate (£20,780 for 2025/26 entry), research costs, and tuition fees at the UK rate. A limited number of full studentships are available for exceptional international (EU and non-EU) applicants due to the competitive nature of the scheme. Eligibility: Open to UK, EU, and international students. Applicants should have, or expect to obtain, at least an upper second-class honours degree or equivalent in a biological, chemical, or physical science or mathematics. The programme welcomes candidates from these backgrounds who are interested in applying their skills to biological research questions. International students must meet the entry requirements of the host university. Application Process: To apply, complete the expression of interest form for October 2026 recruitment at the provided link. For questions about the application process, contact YBDTP@leeds.ac.uk. For informal project enquiries, contact research@bradford.ac.uk or s.kantamneni@bradford.ac.uk. This is an excellent opportunity to join a vibrant, interdisciplinary research environment and contribute to impactful research in neurodegenerative disease intervention.