PhD in Chemistry: Developing Photoactive Caged N-Hydroxysulfonamides for HNO Generation

This fully-funded PhD position at The Dodd-Walls Centre for Photonic and Quantum Technologies offers an exciting opportunity to advance research in the development of photoactive molecules for nitroxyl (HNO) generation. HNO-based drugs have demonstrated significant potential in treating conditions such as congestive heart failure, vascular dysfunction, cancer, and stroke. However, nitroxyl is inherently unstable, rapidly dimerising in aqueous solution and reacting with biomolecules, which complicates its study and application. The project focuses on designing and synthesizing HNO donor molecules that generate HNO in situ, using light activation as a precise and efficient method to release compounds at specific locations and times. The research will involve coupling established phototriggers (chromophores) with HNO donor molecules, followed by detailed studies on the synthesis and photodecomposition mechanisms of these systems. This work is highly interdisciplinary, combining aspects of organic synthesis, analytical chemistry, and photochemistry. The successful candidate will join a vibrant research environment within the School of Science at Auckland University of Technology, collaborating with Professor Nicola Brasch. The position is fully funded for three years, including a stipend of approximately NZ$34,000 per annum and full coverage of tuition fees. Additional funding is available to support the research programme, including travel to conferences, ensuring comprehensive support for academic and professional development. Applicants should have a strong background in chemistry, particularly organic synthesis and analytical chemistry. Both domestic and international candidates are encouraged to apply. The application process involves submitting a brief statement of interest, a CV, and academic transcripts directly to Professor Nicola Brasch. Shortlisted candidates will work closely with the supervisor to develop a research proposal for submission to The Dodd-Walls Centre. The application deadline is March 25, 2026, with the outcome expected in late May. The start date is flexible, anticipated for the second half of 2026. For further information and to apply, please contact Professor Nicola Brasch at [email protected]. Reference recent publications for background on the project, including work on coumarin-caged and nitrophenyl-caged N-hydroxysulfonamides for HNO generation. This PhD opportunity is ideal for candidates seeking to contribute to cutting-edge research in chemical synthesis and photochemistry with biomedical applications.