Bronchiectasis, once considered rare, is now the third most common chronic respiratory disease worldwide, characterized by progressive and irreversible widening of the bronchi. This condition results from a cycle of impaired mucus clearance, recurrent infections, dysregulated inflammation, and airway damage. Despite its increasing prevalence and global burden, the biological mechanisms underlying bronchiectasis remain poorly understood, and there are currently no licensed drug treatments, leaving patients with limited options.

This PhD project at the University of Leicester aims to advance understanding of bronchiectasis by investigating its genetic architecture. Leveraging large-scale genomic datasets from population-based biobanks and clinical cohorts, you will apply advanced bioinformatics and statistical genetic methodologies to identify genetic variants, genes, and pathways associated with disease susceptibility and progression. The research will provide mechanistic insights into bronchiectasis biology and highlight new opportunities for drug development.

You will join the Department of Population Health Sciences and be supported by supervisors with expertise in respiratory genomics and statistical genetics, including Dr Kayesha Coley and Prof L Wain. The project offers access to cutting-edge datasets and methodologies, fostering a collaborative and interdisciplinary research environment.

The College of Life Sciences studentship provides 3.5 years of UK tuition fees and a stipend at UKRI rates (£20,780 per year for 2025/6). International applicants are welcome but must fund the difference between UK and overseas fees (£18,644 per year for 2025/26), as well as visa, NHS, and travel costs. Entry requirements include a first or upper second class undergraduate degree in a relevant subject (genetics, bioinformatics, medical science, biology, or related fields), with desirable experience in statistical genetics, genomics, or bioinformatics. English language proficiency is required for non-native speakers.

The application deadline is March 15, 2026. To apply, review the application advice and submit your application via the University of Leicester research degrees web page. For project enquiries, contact Dr Kayesha Coley at [email protected].