This PhD position at Leiden University is focused on the development of anticancer nanomedicines within the Faculty of Science and the Leiden Academic Centre for Drug Research (LACDR). The project is part of the NanoMed NL consortium, a collaborative effort among Dutch stakeholders to advance nanomedicine research, integrating fundamental science with the creation of novel therapies for cancer and gene therapies for metabolic disorders. The successful candidate will join the Barz lab, where they will develop polypept(o)ide-based nanomedicines aimed at improving current cancer therapies.

The research involves synthesizing functional amino acids, performing solid phase peptide synthesis, and polymerizing N-carboxyanhydrides to produce precision polymers. These polymers will serve as the foundation for constructing functional nanomedicines, with anticancer drugs covalently attached via disease-responsive bonds. The efficacy of these new systems will be evaluated and compared to conventional antibody drug conjugates (ADCs) within the consortium.

The position offers a stimulating and international research environment located in the heart of the Bio Science Park, with access to advanced training and career development opportunities. The appointment is for four years and includes a competitive salary, holiday and end-of-year bonuses, and support for international candidates, such as a substantial tax break and attractive secondary employment terms. Applicants should possess a strong background in synthetic chemistry, ideally with experience in peptide synthesis, NCA polymerization, or synthetic organic chemistry, and must hold a relevant master's degree.

The application process requires submission of a cover letter, CV, transcripts, and reference letters, followed by an interview and a writing assessment. Leiden University values diversity and inclusion, striving to create a supportive and collaborative academic community.