ETH Zürich invites applications for a PhD position in Biofluid Sampling Technologies for Localized Physiological Measurements (SDC19), embedded within the Horizon Europe ENDOTRAIN Doctoral Training Network. ENDOTRAIN aims to revolutionize the diagnosis and management of adrenal disorders by integrating clinical endocrinology, artificial intelligence, data science, engineering, ethics, and law into digital endocrinology. The successful candidate will join a vibrant interdisciplinary environment at the Department of Mechanical and Process Engineering and the Department of Health Sciences and Technology, co-hosted by the Human-centered Sensing Laboratory (Prof. Andreas Güntner) and the Laboratory of Exercise and Health (Prof. Katrien de Bock).

This PhD project focuses on developing micromachined platforms for minimally invasive and localized access to biofluids, such as interstitial fluid or muscle tissue, enabling direct and continuous sampling and analysis of metabolites, hormones, and other physiological markers. The research is poised to transform diagnostic and monitoring strategies in sports science, rehabilitation, and muscle-related diseases. Specific tasks include designing and fabricating advanced microfabricated systems (e.g., microneedles, implantables, microfluidics), investigating concepts for minimal tissue disruption and high analyte recovery efficiency, quantifying analyte concentrations dynamically in mouse models and humans, and developing models for local production, metabolism, and diffusion of analytes.

The position offers secondments at the University of Bergen (validation of sampling strategy) and University Hospital Zurich (testing of samplers on humans), providing opportunities for international collaboration and practical application. ETH Zürich provides a competitive salary according to Swiss National Science Foundation regulations, full social security coverage, travel and secondment budget, and a supportive, inclusive, and diverse working environment. The PhD student will participate in mandatory interdisciplinary training activities across the ENDOTRAIN network, including workshops, retreats, transferable skills courses, and cohort-wide meetings across Europe.

Applicants must hold a Master’s degree in Biomedical Engineering, Physiology, Mechanical Engineering, Materials Science, or a related field, demonstrate strong interest in translational health technologies, possess excellent English skills, and show capacity for interdisciplinary collaboration. Ideally, candidates will have experience in microfabrication, biocompatible materials, and implantables. Eligibility criteria include not having resided or carried out main activity in Switzerland for more than 12 months in the 36 months before recruitment. The application deadline is before August 2026.

To apply, submit a single merged PDF via the ETH online portal, including a cover letter, CV, transcripts, references, and representative research work. For informal inquiries, contact Prof. Andreas Güntner at [email protected]. More information about the research groups can be found at the Human-centered Sensing Laboratory and Laboratory of Exercise and Health websites. ETH Zürich is committed to diversity, sustainability, and excellence in research and education.