PhD Position: Liposomal Antibiotic for Improved Treatment of Respiratory Infection Queen’s University Belfast in United Kingdom

This PhD opportunity at Queen’s University Belfast, School of Pharmacy, focuses on the development of liposomal antibiotics for improved treatment of respiratory infections, particularly in the context of antimicrobial resistance (AMR). AMR is a critical global health challenge, leading to increased mortality, longer hospital stays, and higher healthcare costs. Chronic respiratory diseases such as Cystic Fibrosis (CF) and COPD are characterized by persistent lung infections with diverse bacterial communities, where current inhaled antibiotic therapies face limitations in drug penetration and efficacy.

The research group has developed advanced powder formulations suitable for pulmonary delivery, demonstrating that several antibiotics can be effectively encapsulated for targeted lung delivery. The project aims to evaluate the antimicrobial activity of these nanoparticle-encapsulated antibiotics using both planktonic and biofilm models of infection. Formulation optimization studies will be conducted to enhance antimicrobial effectiveness, with a strong emphasis on physicochemical characterization, thermal stability, and microbiological activity of the products.

Extensive training is provided in nanoparticle manufacture, experimental design, and statistical analysis, ensuring students gain comprehensive skills in pharmaceutical formulation and drug delivery. The project is embedded within internationally recognized research teams and is expected to contribute to high-impact publications, advancing the field of inhaled antibiotic therapies.

Applicants should possess an MPharm or BSc Hons degree in Pharmaceutical Sciences, Pharmaceutical Biotechnology, Biochemistry, Microbiology, Chemistry, Engineering, or a related discipline. Desirable skills include experience in pharmaceutical formulation and protein purification. Candidates must demonstrate motivation, teamwork, effective communication, and a strong commitment to research excellence. Applications are accepted year-round, and candidates should apply via the Queen’s University Belfast Direct Applications Portal, ensuring their CV and application are specifically tailored to this studentship.

For further details, visit the School of Pharmacy’s postgraduate research pages. This position offers a unique opportunity to contribute to the development of innovative treatments for bacterial lung infections and to address the urgent issue of antimicrobial resistance.