The Centre for Brain Research (CBR) at the Indian Institute of Science (IISc), Bangalore, is seeking motivated postdoctoral candidates with strong prior experience in structural biology, specifically in cryo-EM or NMR, to join a research group led by Dr. Sivaprakasam Ramamoorthy, Assistant Professor and Principal Investigator. The lab focuses on understanding the molecular mechanisms underlying protein misfolding and its role in the progression of neurodegenerative diseases such as Alzheimer's disease, progressive supranuclear palsy (PSP), and Pick’s disease (PiD).

Research in the group is highly interdisciplinary, combining structural biology, molecular biology, and protein biochemistry to elucidate the triggers and pathways of tau and alpha-synuclein misfolding. The lab also investigates the molecular basis of Alzheimer’s disease progression, tau isoform-specific aggregation, and develops drug candidates targeting tauopathies. Additional interests include identifying fluid-based biomarkers to predict and monitor dementia progression, contributing to innovative diagnostic and therapeutic strategies for neurodegenerative diseases.

The position is fully funded through extramural grants from DBT-India, ICMR-India, SERB-India, and the Alzheimer’s Association-USA. The research environment is collaborative, with opportunities to work alongside PhD students, postdoctoral fellows, and project assistants. The lab has a strong publication record in high-impact journals, reflecting its commitment to advancing the field of neuroscience and neurodegeneration.

Applicants should have a PhD in a relevant field and demonstrated expertise in structural biology techniques such as cryo-EM or NMR. Experience in molecular biology and protein biochemistry is desirable. Interested candidates are encouraged to contact Dr. Sivaprakasam Ramamoorthy directly at [email protected]. For more information about the lab and its research, visit the academic profile page.

This is an excellent opportunity for postdoctoral researchers interested in neurodegenerative disease mechanisms, protein misfolding, and interdisciplinary biomedical research at one of India’s premier research institutions.