The Centre de recherche des Cordeliers (CRC) in Paris is offering a postdoctoral position for a researcher specializing in multi-omics within the SIGN’IT Project (MIMIC). This project, funded by Horizon Europe and Inserm, focuses on a multimodal multi-omics approach to predict response to immunotherapy in advanced hepatocellular carcinoma (HCC). The research environment is highly interdisciplinary, bringing together genomic experts, immunologists, pathologists, artificial intelligence specialists, and clinician-scientists. The CRC provides access to state-of-the-art sequencing platforms, digital pathology resources, bioinformatics infrastructure, and well-annotated clinical cohorts.

The postdoctoral researcher will contribute primarily to biomarker discovery and integrated predictive modeling. Key responsibilities include performing and analyzing tumor whole-exome sequencing (WES) and RNA-seq in discovery cohorts, conducting high-throughput serum proteomic analyses, integrating molecular datasets, and validating candidate biomarkers in independent cohorts. The role also involves developing integrative multi-modal models that combine clinical, genomic, and immune analyses, participating in predictive modeling of oncological outcomes and treatment response, and contributing to the identification of novel therapeutic targets.

Main activities encompass bioinformatic analysis of WES and RNA-seq data, variant calling, annotation, mutational signature analysis, differential gene expression and pathway analyses, integration of multi-omics datasets (genomics, transcriptomics, proteomics), statistical modeling, and survival analysis. The researcher will collaborate with AI specialists for histology-based prediction models and will be expected to prepare manuscripts and present results at international conferences.

Applicants must hold a PhD in genomics, bioinformatics, computational biology, molecular oncology, or a related field. Essential skills include strong expertise in NGS data analysis (WES, RNA-seq), proficiency in R and/or Python for statistical and bioinformatic analyses, and experience in integrative multi-omics analysis. Knowledge of biostatistics and survival modeling is required. The ideal candidate will be able to work in a multidisciplinary and translational research environment and possess excellent scientific English. Additional skills such as experience in cancer immunology or immunotherapy research, familiarity with circulating biomarkers (ctDNA, immune profiling), and experience working with large clinical cohorts are appreciated.

The position is a fixed-term postdoctoral contract for 12 months, renewable, with full-time employment (35 hours per week). The application deadline is May 1, 2026, and the expected start date is April 1, 2026. Interested candidates should send their application and CV to [email protected] and review the project details at https://crcordeliers.fr/. For further information, applicants may contact the provided email address.