Studying R-loop Formation in 2D and 3D Tumor Hypoxia Models and Its Impact on Cell Survival Institute of Experimental Medicine of the Czech Academy of Sciences in Czech Republic

This PhD opportunity at the Institute of Experimental Medicine of the Czech Academy of Sciences focuses on investigating R-loop formation in both 2D and 3D tumor hypoxia models and its impact on cell survival. Hypoxia, or reduced oxygen availability, is a defining feature of solid tumors, resulting from the limited penetration of nutrients through the deregulated tumor microenvironment. Understanding how hypoxia influences genetic and molecular processes such as R-loop formation is crucial for advancing cancer biology and developing new therapeutic strategies.

The research will integrate advanced techniques in cancer biology, genomics, molecular genetics, and human genetics to explore the mechanisms by which hypoxic conditions affect tumor cell survival. The project will utilize both traditional 2D cell culture models and innovative 3D tumor models to closely mimic the in vivo tumor environment. This approach allows for a comprehensive analysis of how R-loops contribute to cellular responses under hypoxic stress, potentially revealing novel targets for cancer treatment.

Supervision will be provided by Dr MA Andrš, an expert in molecular genetics and cancer research. The successful candidate will join a dynamic research department with access to state-of-the-art facilities and collaborative opportunities within the Czech Academy of Sciences. While funding details are not specified, applicants are encouraged to inquire about potential support and scholarships.

Eligibility requirements include a degree in biology, medical science, genetics, molecular biology, or a related discipline. Prior laboratory experience, especially in cell culture and molecular techniques, is highly valued. Candidates should demonstrate a strong motivation for cancer research and possess proficiency in English. The application deadline is 31 March 2026, providing ample time for interested students to prepare their materials.

To apply, visit the project link and follow the instructions provided by the Institute. Prepare your CV and supporting documents, and contact the supervisor for further information if needed. This position offers a unique opportunity to contribute to cutting-edge cancer research in a leading European institution.