PhD in Plant-Based Diet in Low Back Pain: Impact on Pain, Gut Microbiome, and Inflammation

The PLANTIP project at Vrije Universiteit Brussel offers an exciting PhD opportunity to investigate the impact of a plant-based diet on chronic low back pain (CLBP), gut microbiome, and inflammation. This interdisciplinary research is led by Prof. Anneleen Malfliet (Pain in Motion, PAIN), Prof. Doris Vandeputte (AI supported modelling in Clinical Sciences, AIMS), Prof. Deliens (Movement and Nutrition for Health and Performance, MOVE), and Prof. Broux (Chronic Inflammation and Blood brain barrier disruption in Neurodegeneration, CBN, Hasselt University). The project brings together expertise in chronic pain, lifestyle interventions, microbiology, nutrition, and inflammatory processes. CLBP is a major cause of disability worldwide, with current rehabilitation approaches often failing to deliver optimal long-term outcomes. Recent evidence suggests that CLBP is influenced by lifestyle factors, particularly diet and nutrition. Individuals with CLBP tend to have poorer diet quality, characterized by lower intake of vegetables and whole grains. Plant-based diets are known to enhance gut microbiome diversity and stability, and are associated with reduced systemic inflammation. The PLANTIP project is a double-blind, randomized controlled clinical trial with a 12-month follow-up. It aims to determine whether combining an anti-inflammatory plant-based diet with contemporary physiotherapy leads to a significant reduction in self-reported pain intensity compared to a plant-based diet alone or physiotherapy alone. The study will also assess secondary outcomes such as changes in diet quality, systemic inflammatory markers, gut microbiota composition, physical function, quality of life, and mental wellbeing. This integrative research design will help elucidate the biological pathways through which dietary modulation may influence chronic pain, particularly via inflammation and gut dysbiosis. By embedding mechanistic analyses within a rigorous clinical trial, PLANTIP seeks to bridge gaps between nutrition science, chronic pain mechanisms, and rehabilitation practice. The successful candidate will be based at the Brussels Health Campus (Jette) and will work closely with leading research groups in the field. Applicants should have a relevant Master's degree and a strong interest in pain research, nutrition, and clinical trials. Experience with clinical research, rehabilitation, or microbiome analysis is advantageous. Good communication skills and proficiency in English are expected. The position offers a unique opportunity to contribute to innovative research with real-world impact on health and wellbeing. To apply, visit the university's job portal and submit your CV, motivation letter, and academic documents. For further information, contact the research groups involved.