Disrupted Brain Development and Stress Responses in a Zebrafish Model of Psychiatric Disease Aston University in United Kingdom

This PhD project at Aston University investigates how early brain development influences stress regulation, using zebrafish as a model system to study psychiatric disease mechanisms. Psychiatric disorders such as schizophrenia, depression, and anxiety are major global health challenges, often characterized by altered stress responses. However, the developmental and genetic factors underlying this vulnerability remain poorly understood.

The research will focus on the role of the psychiatric risk gene Disrupted-In-Schizophrenia-1 (DISC1) in shaping stress-regulating circuits of the hypothalamus. Previous work in the lab has shown that mutations in DISC1 affect both brain development and stress hormone responses in zebrafish. Building on these findings, the project will explore how DISC1 and related molecular pathways influence the development and function of neurons that control stress, using advanced imaging, molecular genetics, behavioural assays, and bioinformatics approaches.

The successful candidate will receive comprehensive training in zebrafish developmental neurobiology, stress physiology, and cutting-edge techniques for imaging and genetic manipulation. The project is ideal for students with backgrounds or interests in neuroscience, developmental biology, genetics, or biomedical science, and offers excellent interdisciplinary research training in a supportive environment.

Funding covers Home tuition fees; overseas applicants are welcome but must pay the difference between Home and Overseas tuition fees (£17,712 for 2026/7). Applicants must have, or expect to achieve, a First or Upper Second Class undergraduate degree (or equivalent) in a relevant subject, or a Merit or above in a relevant postgraduate Masters degree. All applicants must provide transcripts, research and personal statements, a CV, two academic references, evidence of English language proficiency, and a passport copy. The project is based at Aston Campus in Birmingham, UK, and students are expected to attend in person regularly.

Applications are accepted year-round. For further information, contact Dr Helen Eachus at [email protected]. Apply via the provided link, selecting 'Research - Health Sciences' on the application form.