This fully funded PhD project at the University of Bristol explores the intersection of immunity and memory by investigating the novel roles of antimicrobial peptides (AMPs) in neural function. Both the neural and immune systems process external cues and coordinate responses, and recent research suggests they share functional mechanisms. AMPs, traditionally known for their role in combating infections, have been implicated in neural function and neurodegeneration, with upregulation observed in Alzheimer’s disease and links to dendrite degeneration in invertebrate models. The project focuses on the Baramicin family of AMP genes in Drosophila, with Baramicin A potentially offering neuroprotection and Baramicin B and C enriched in the nervous system. The research aims to: (1) investigate AMP expression in neural and glial subtypes using imaging and connectomic approaches; (2) assess the roles of different AMPs in memory and sensory perception through genetic manipulation and mutant panels; and (3) study AMP involvement in neurodegeneration using Drosophila models of Alzheimer’s disease. The student will gain expertise in molecular, behavioural, and brain imaging techniques, and join vibrant neuroscience and immunity communities in the South West. The SWBio DTP supports students from diverse backgrounds, offering reasonable project adaptations and flexible study options. The studentship includes a stipend of £20,780 per year, full tuition, research costs, and additional funds for fieldwork, conferences, and placements. Up to 30% of studentships are available for international applicants. The outcomes of this research will advance understanding of AMP modulation of neural function and may inform new therapeutic approaches for neurodegenerative disorders. Applications are open until December 3, 2025, and further details are available on the SWBio DTP website.