This fully funded PhD project at the University of Bristol investigates the mechanisms underlying circadian rhythms and their impact on healthy ageing. Circadian rhythms are essential for synchronizing physiology and behaviour with environmental light/dark cycles, and their disruption is linked to ageing and disease, particularly in the elderly and those with neurodegenerative conditions. The project focuses on the molecular and membrane clocks within clock neurons, exploring how their synergy weakens over the lifespan and contributes to compromised circadian rhythms and health. You will address key knowledge gaps by studying the role of clock neuron excitability, the mechanisms of the membrane clock, interactions between molecular and membrane clocks, and the influence of ageing signalling pathways. The research aims to identify interventions that can reverse age-dependent decline in these clocks, potentially leading to chronotherapies for ageing. The project spans multiple levels of analysis, from mathematical modelling to whole-organism studies, and seeks to uncover evolutionary conserved mechanisms and interventions to rejuvenate circadian rhythms. The SWBio DTP provides outstanding interdisciplinary bioscience training, with access to world-class facilities and networks. The studentship includes a generous stipend, full tuition, research costs, and additional support for fieldwork, conferences, and placements. The programme is committed to supporting students from diverse backgrounds, offering flexibility and reasonable adaptations to ensure accessibility. Applicants should have a strong background in relevant disciplines and an interest in interdisciplinary research. The application deadline is December 3, 2025, and further details on eligibility and funding are available on the SWBio DTP website.