PhD Studentship: Marie Curie MetaExplore PhD position (Functional Metagenomics and Biocatalyst Discovery) University of Cambridge in United Kingdom

[Marie Curie Rates; fixed-term funding available until 31st January 2030.]

This PhD studentship at the University of Cambridge is part of the prestigious Marie Curie MetaExplore network, focusing on functional metagenomics and the discovery of novel biocatalysts for a sustainable circular economy. The successful candidate will join Professor Florian Hollfelder's group in the Department of Biochemistry, working on the development of ultrahigh throughput assays to screen metagenomic libraries for new catalysts. These catalysts have potential applications in recycling, bioremediation, and green chemistry, contributing to resource and energy efficiency in future sustainable processes.

The project leverages advanced microfluidic technologies to enable ultrahigh-throughput screening, allowing experimental interrogation of enzyme libraries with over 10 million members per day. Candidate enzymes will be mechanistically investigated, structurally characterised, and improved through directed evolution. The position offers extensive training opportunities through collaborations with MetaExplore network partners across Europe, encompassing both experimental and computational approaches.

Applicants should possess a first or upper second class degree in chemistry, biochemistry, or a closely related field. Experience with molecular and chemical biology techniques is essential, and additional skills in assay development, enzyme kinetics, DNA library generation, structural biology, organic synthesis, high-throughput screening, mechanistic enzymology, bioinformatics, and microfluidic engineering are highly desirable. The position is funded at Marie Curie rates, with support available until 31st January 2030.

To apply, candidates should submit a cover letter outlining their research interests, a detailed CV including exam marks and practical experience, a list of publications, and the names and email addresses of at least two referees. The University of Cambridge is committed to equality, diversity, and inclusion, and encourages applications from all backgrounds. For informal enquiries, contact Professor Florian Hollfelder at [email protected]. The application deadline is 25 March 2026.