This ERC-funded postdoctoral position at KU Leuven focuses on the multiscale modeling of cartilage mechanics within the OA-CONNECT project, which aims to unravel why mechanical loading, typically beneficial for cartilage and chondrocytes, becomes detrimental in osteoarthritis (OA). The research bridges joint mechanics and cellular processes using a multidisciplinary approach that integrates in vitro, in silico, and in vivo methodologies. The successful candidate will develop advanced multiscale models to mechanistically relate mechanical loading at the cartilage surface to the cell’s microenvironment and molecular processes.

Key responsibilities include utilizing finite element models of cartilage deformation validated by deformation microscopy and MRI, adapting gene regulatory network models to align molecular transduction processes in OA chondrocytes with bioreactor study results, and integrating imaging techniques such as PET-MRI and molecular read-outs. The project offers a unique opportunity to gain unprecedented insights into cartilage degeneration and mechanobiological mechanisms, enabling non-invasive detection of tissue and microstructural changes in both healthy and OA-affected cartilage. The postdoctoral researcher will design, execute, and analyze model-based workflows, apply inverse finite element modeling for mechanical characterization, and integrate diverse data into a coherent mechanobiological framework.

Collaboration with a multidisciplinary team of engineers, biologists, and clinicians is central, as is dissemination of research through publications, conferences, and science communication. The position also involves supervising master’s and PhD students and contributing to a supportive research culture. Applicants should have a PhD in biomedical sciences or a related field, strong quantitative and modeling skills, and experience in interdisciplinary research.

The appointment is full-time for one year, with the possibility of extension, and includes access to state-of-the-art molecular analysis and imaging facilities, advanced computing infrastructure, and active career development support. KU Leuven provides an inclusive and diverse research environment. The application deadline is December 1, 2025. For further details, candidates may contact Prof. dr.

Ilse Jonkers or Mr. Ali Elahi.