Alfred Vertegaal at Leiden University - Research Interests, Publications & Academic Profile

Alfred Vertegaal

Professor

Leiden University

Netherlands

Has grant

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Research Interests

Biochemistry

100%

Cell Biology

100%

Cancer Biology

50%

Protein Expression

40%

Proteasome Biology

40%

Dna Damage

30%

Molecular Biology

30%

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Recent Grants

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Cracking the SUMO Signalling Code

Open Date: 2013-01-01

Close Date: 2017-12-31

Grant: Close

The Ubiquitin-Proteasome System is a Key Component of the Cellular SUMO-2/3 Cycle

Open Date:

Close Date:

Grant: Close

Uncovering the role of sumoylation in pre-mRNA splicing

Open Date:

Close Date:

Grant: Close

Cracking the Mitotic SUMO-Phospho Signaling Code

Open Date:

Close Date:

Articles16

SUMO proteases: from cellular functions to disease

Article Link

Year:

2024

Inhibition of SUMOylation enhances DNA hypomethylating drug efficacy to reduce outgrowth of hematopoietic malignancies

Article Link

Year:

2023

The lncRNA LETS1 promotes TGF-β–induced EMT and cancer cell migration by transcriptionally activating a TβR1-stabilizing mechanism

Article Link

Year:

2023

BioE3 identifies specific substrates of ubiquitin E3 ligases

Article Link

Year:

2023

SENP6 regulates localization and nuclear condensation of DNA damage response proteins by group deSUMOylation

Article Link

Year:

2023

Exome sequencing links the SUMO protease SENP7 with fatal arthrogryposis multiplex congenita, early respiratory failure and neutropenia

Article Link

Year:

2023

A disease-associated XPA allele interferes with TFIIH binding and primarily affects transcription-coupled nucleotide excision repair

Article Link

Year:

2023

In-plate Chemical Synthesis of Isopeptide-linked SUMOylated Peptide Fluorescence Polarization Reagents for High-Throughput Screening of SENP preferences.

Article Link

Year:

2022

Targeting pancreatic cancer by TAK-981: a SUMOylation inhibitor that activates the immune system and blocks cancer cell cycle progression in a preclinical model

Article Link

Year:

2022

Divergent Molecular and Cellular Responses to Low and High-Dose Ionizing Radiation

Article Link

Year:

2022

Signalling mechanisms and cellular functions of SUMO

Article Link

Year:

2022

Deubiquitinating enzymes and the proteasome regulate preferential sets of ubiquitin substrates

Article Link

Year:

2022

A CSB-PAF1C axis restores processive transcription elongation after DNA damage repair.

Article Link

Year:

2021

Splicing factors control triple-negative breast cancer cell mitosis through SUN2 interaction and sororin intron retention

Article Link

Year:

2021

Identification of proximal SUMO-dependent interactors using SUMO-ID.

Article Link

Year:

2021

Site-specific proteomic strategies to identify ubiquitin and SUMO modifications: Challenges and opportunities.

Article Link

Year:

2021

Collaborators13

Peter van Veelen

Leiden University Medical Center

NETHERLANDS

Tanveer Singh Batth

Københavns Universitet

DENMARK

Blagoy Blagoev

University of Southern Denmark

DENMARK

Bharath Sampadi

Leiden University Medical Center

NETHERLANDS

Girish Shah

Laval University

CANADA

Jurgen Marteijn

Professor

Erasmus MC

NETHERLANDS

Gerbrand van der Heden van Noort

Assistant professor (Principal Investigator)

Leiden University Medical Center

NETHERLANDS

Remco van Doorn

Leiden University Medical Center

NETHERLANDS

Mirjam H.M. Heemskerk

Associate professor, Head of Laboratory of experimental hematology

Leiden University Medical Center

NETHERLANDS

Noel de Miranda

Professor

Leiden University Medical Center

NETHERLANDS

Román González-Prieto

Leiden University Medical Center

NETHERLANDS

Lucia Daxinger

Leiden University Medical Center

NETHERLANDS

Peter ten Dijke

Leiden University Medical Center

NETHERLANDS

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