Synthesis and Evaluation of Novel BCL6 Targeting Degraders for Aggressive B Cell Malignancies

This PhD opportunity at the University of Leicester focuses on the synthesis and evaluation of novel BCL6-targeting degraders for the treatment of aggressive B cell malignancies. The project is based in the Department of Chemistry and involves interdisciplinary research at the interface of chemistry, biology, and medical science. The supervisory team includes Dr. JH Hodgkinson (lead supervisor), Dr. Harriet S. Walter (Genetics and Genome Biology, University of Leicester), and Professor Sarah Dimeloe (Department of Immunology and Immunotherapy, University of Birmingham), providing expertise in synthetic chemistry, cancer biology, and immunology. Research areas covered by this project include cancer biology, cell biology, molecular biology, computational chemistry, organic chemistry, pharmaceutical chemistry, and synthetic chemistry. The aim is to design, synthesize, and evaluate small molecule degraders that specifically target BCL6, a key protein implicated in the pathogenesis of aggressive B cell cancers. The project will utilize advanced synthetic chemistry techniques, computational modeling, and biological assays to assess the efficacy and mechanism of action of candidate compounds. Applicants should have a strong background in chemistry, biochemistry, molecular biology, or a related discipline. Experience in synthetic or computational chemistry, as well as cancer biology, is highly desirable. The project offers an excellent opportunity to develop skills in drug discovery, interdisciplinary research, and translational science, working within a collaborative environment that spans multiple departments and institutions. Funding details are not specified in the current announcement. Prospective students are encouraged to check the University of Leicester website or contact the supervisors for further information regarding funding options. The application deadline is 9 January 2026, and candidates should ensure all required documents are submitted before this date. To apply, candidates should use the University of Leicester's online application portal, preparing a CV, academic transcripts, and a personal statement outlining their research interests and suitability for the project. Informal inquiries to the supervisors are welcome for further details about the research and application process.