STEFANO MANGANI at University of Siena - Research Interests, Publications & Academic Profile

STEFANO MANGANI

Full Professor of Chemistry

University of Siena

Italy

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Research Interests

Pharmaceutical Chemistry

70%

Biochemistry

80%

Chemical Biology

50%

Ligand Design

40%

Drug Development

40%

Protein Chemistry

40%

Antibiotic Discovery

20%

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Articles12

Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti-Trypanosoma brucei Agents

Article Link

Year:

2024

Metal Ion Binding to Human Glutaminyl Cyclase: A Structural Perspective

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Year:

2024

Copper Binding and Redox Activity of α-Synuclein in Membrane-Like Environment

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Year:

2023

Structural Characterization of Human Heat Shock Protein 90 N-Terminal Domain and Its Variants K112R and K112A in Complex with a Potent 1,2,3-Triazole-Based Inhibitor

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Year:

2022

Xanthopsin‐Like Systems via Site‐Specific Click‐Functionalization of a Retinoic Acid Binding Protein

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Year:

2022

Crystal structure of the ternary complex of Leishmania major pteridine reductase 1 with the cofactor NADP+/NADPH and the substrate folic acid

Article Link

Year:

2022

Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases

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Year:

2021

Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin

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Year:

2021

Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of Trypanosoma brucei Pteridine Reductase and Dihydrofolate Reductase

Article Link

Year:

2021

Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations

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Year:

2021

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–7

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Year:

2020

High-resolution crystal structure of Trypanosoma brucei pteridine reductase 1 in complex with an innovative tricyclic-based inhibitor

Article Link

Year:

2020

Collaborators23

Maria Paola Costi

University of Modena and Reggio Emilia

ITALY

Jussara Amato

University of Naples Federico II

ITALY

George Kokotos

National and Kapodistrian University of Athens

GREECE

Maurizio Pellecchia

Professor

University of California

UNITED STATES

Diego Muñoz-Torrero

Full Professor of Organic & Medicinal Chemistry

University of Barcelona

SPAIN

Marco Bisaglia

University of Padova

ITALY

Michael Gütschow

University of Bonn

GERMANY

ELENA PETRICCI

Professor

University of Siena

ITALY

Federico Galvagni

Prof.

University of Siena

ITALY

Luigi Bubacco

Full Professor

University of Padua

ITALY

ENRICO MONZANI

Full professor

University of Pavia

ITALY

Cecilia Pozzi

Associate Professor

University of Siena

ITALY

Katalin Prokai-Tatrai

Professor

University of North Texas Health Science Center

UNITED STATES

Francesca Camponeschi

University of Florence

ITALY

Glauco Ponterini

University of Modena and Reggio Emilia

ITALY

Ivan Kosalec

CROATIA

Paola Turano

University of Florence

ITALY

MICHELE TONELLI

Associate Professor

University of Genoa

ITALY

Yasu-Taka Azuma

JAPAN

Peter Scott

Associate Professor

University of Michigan

UNITED STATES

Jarkko Rautio

Professor in pharmaceutical chemistry

University of Eastern Finland

FINLAND

Domenico D’Arca

University of Modena and Reggio Emilia

ITALY

Daniela Valensin

University of Siena

ITALY

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