James Spencer
Top university
5 months ago
Overcoming ß-lactamase-mediated antibiotic resistance GW4 BioMed DTP in United Kingdom
Degree Level
PhD
Field of study
Molecular Biology
Funding
This is a fully funded 4-year PhD position through the GW4 BioMed Doctoral Training Programme. Funding includes tuition fees and a stipend at the UKRI rate. Additional support for research costs is provided. The position is open to UK and international applicants.
Deadline
Expired
Country
United Kingdom
University
University of Bristol
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About this position
Funding details
This is a fully funded 4-year PhD position through the GW4 BioMed Doctoral Training Programme. Funding includes tuition fees and a stipend at the UKRI rate. Additional support for research costs is provided. The position is open to UK and international applicants.
What's required
Applicants must hold or expect to obtain a first or upper second class degree (or equivalent) in a relevant subject such as biology, chemistry, biochemistry, biomedical sciences, or a related field. Experience or strong interest in computational biology, molecular simulation, or experimental biochemistry is desirable. Selection is highly competitive. International applicants may need to meet English language requirements (e.g., IELTS/TOEFL).
How to apply
Contact Marc van der Kamp by October 5th with a draft of your application text fields. Apply through the GW4 BioMed DTP website before October 20th. Review project details and eligibility on the provided link.
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Details:
*Overcoming ß-lactamase-mediated antibiotic resistance by combining biomolecular simulation and experiment*
GW4 Biomed Doctoral Training Programme 4 year PhD project
Co-supervisors: James Spencer , Catherine Tooke , Adrian Mulholland
Antibiotic resistance threatens human health. ß-lactamases cause resistance to ß-lactams, the most widely used antibiotics. Class C ß-lactamases are not well understood, but variants are emerging that help bacteria evade even ‘last resort’ treatments. By combining computer simulation (molecular dynamics, reaction simulations) and experimental methods (enzyme assays, crystallography) you will study how, finding links between structure and activity. This will help to regain the upper hand in the ‘biochemical warfare’ between humans and bacteria. The focus will be on the use of multiscale (QM/MM and ML/MM) reaction simulations.
Related publication: A. H. Lima, M. W. van der Kamp, 2025. Insights into the Enhanced Ceftazidime Hydrolysis by Ent385 AmpC ß-Lactamase from Multiscale Simulations. ACS Catal., 15, 11739–11748, DOI: 10.1021/acscatal.5c02383.
More information on project and DTP:
https://lnkd.in/e7ZC3wFR
Applications close Oct 20th, but please contact me before applying to the DTP (by October 5th), with a draft for the text fields on the application form.