This PhD position at Eindhoven University of Technology focuses on advancing positive airway pressure (PAP) therapy for sleep apnea, specifically obstructive sleep apnea (OSA), a common disorder that disrupts breathing during sleep and increases risks for cardiovascular disease, diabetes, depression, and daytime sleepiness. The project is based in the Biomedical Diagnostic (BM/d) Lab, part of the Signal Processing Systems group in the Electrical Engineering department, and involves collaboration with the Center for Sleep Medicine Kempenhaeghe and Philips Sleep & Respiratory Care. The research aims to improve understanding of PAP therapy's effects on sleep quality and patient outcomes, with a particular emphasis on both objective and subjective measurements during home-based auto-titration periods. The candidate will set up and run a clinical data collection trial, analyze physiological and subjective sleep data, and apply advanced statistical and data analysis methods to relate these findings to therapeutic outcomes. The project is embedded within the Eindhoven MedTech Innovation Center (e/MTIC), a public-private partnership focused on high-tech health innovations, especially in sleep, perinatal, and cardiovascular fields. The BM/d lab has a strong track record in electrophysiological signal processing, physiological modelling, and biosignal analysis. The position offers full-time employment for four years, with a competitive salary and benefits according to Dutch university standards, including pension, paid leave, bonuses, and support for international candidates. Applicants should have a MSc in a relevant field, experience with biomedical trials and physiological signal processing, and fluency in English and Dutch. The successful candidate will work in a multidisciplinary, international environment, with opportunities for teaching and professional development. Applications are accepted online until the position is filled, with a formal screening process in place.