Bioinspired Total Synthesis of Complex Natural Products

This PhD project at the University of Southampton, supervised by Associate Professor Jonathan George and Dr. Sam Thompson, explores the bioinspired total synthesis of complex natural products. The research aims to mimic nature’s biosynthetic pathways using synthetic chemistry, focusing on developing efficient and sustainable strategies for constructing three-dimensionally complex molecules, particularly meroterpenoids. These natural products are assembled from distinct molecular building blocks and exhibit remarkable structural diversity and medicinal importance. A central theme of the project is the transformation of simple aromatic molecules into complex polycyclic structures, a process achieved in nature through cascade reactions. The research seeks to replicate this efficiency in the laboratory by designing biomimetic cascade reactions inspired by natural biosynthetic pathways. The project will provide expert training in synthetic organic chemistry, advanced analytical techniques such as Nuclear Magnetic Resonance (NMR) analysis and single crystal x-ray diffraction, and opportunities to collaborate with biochemists and other specialists. The George Group has a strong track record in concise, biomimetic total syntheses of complex molecules, integrating modern methods like photoredox catalysis, photochemistry, and biocatalysis. Their work often involves structure revision of natural products and the prediction and isolation of new compounds. The ultimate goal is to discover new ways to synthesize complex natural products rapidly and efficiently, sometimes in a single step. Applicants must hold a UK 2:1 honours degree or its international equivalent. The School of Chemistry and Chemical Engineering is committed to equality, diversity, and inclusivity, offering flexible working patterns and support for those who have taken a career break. The University provides a generous maternity policy, onsite childcare, and a range of benefits to support well-being and work-life balance. Sustainability is a core value, as demonstrated by the Platinum EcoAward. Funding is available through various bursaries and scholarships for both UK and international students. Horizon Europe fee waivers and competition-based Presidential Bursaries may cover fee differences for qualifying students. Funding is awarded on a rolling basis, so early application is recommended. The application deadline is August 31, 2026. To apply, select programme type (Research), 2026/27, Faculty of Engineering and Physical Sciences, and choose PhD Chemistry (7189). Include the supervisor’s name in section 2 and submit your CV, two academic references, degree transcripts and certificates, and English language qualification if applicable. For general questions, email [email protected] or contact [email protected] for an initial conversation.