Leendert Trouw at Leiden University Medical Center - Research Interests, Publications & Academic Profile

Leendert Trouw

Professor

Leiden University Medical Center

Netherlands

Has grant

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ORCID

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Research Interests

Immunology

100%

Biochemistry

60%

Inflammatory Biology

70%

Antibodies

60%

Autoimmunity

50%

Arthritis

40%

Protein Chemistry

30%

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Recent Grants

Grant: Close

ERC Consolidator Grant - The role of complement in the induction of autoimmunity against post-translationally modified proteins.

Open Date: 2017-01-01

Close Date: 2022-01-01

Grant: Close

NWO-VIDI - Understanding the pathological processes of Rheumatoid Arthritis by the analysis of a novel family of auto-antibodies (anti-CarP)

Open Date: 2012-01-01

Close Date: 2017-01-01

Grant: Close

NWO-VENI - Inhibiting the initiators; the role of complement inhibitors in the prevention of autoimmunity

Open Date: 2007-01-01

Close Date: 2010-01-01

Articles16

Structural basis for surface activation of the classical complement cascade by the short pentraxin C-reactive protein

Article Link

Year:

2024

Circulating levels of endogenous complement inhibitors correlate inversely with complement consumption in systemic lupus erythematosus

Article Link

Year:

2024

Autoimmune hepatitis displays distinctively high multi-antennary sialylation on plasma N-glycans compared to other liver diseases

Article Link

Year:

2024

Differences in avidity of anti-post-translationally modified protein antibodies in mouse models and rheumatoid arthritis patients: not one-size-fits-all

Article Link

Year:

2024

Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domains

Article Link

Year:

2023

Antibodies against advanced glycation end-products and malondialdehyde-acetaldehyde adducts identify a new specific subgroup of hitherto patients with seronegative arthritis with a distinct clinical phenotype and an HLA class II association

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Year:

2023

Type 17-specific immune pathways are active in early spondyloarthritis

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Year:

2023

Host biomarker-based quantitative rapid tests for detection and treatment monitoring of tuberculosis and COVID-19.

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Year:

2022

Added value of multiple autoantibody testing for predicting progression to inflammatory arthritis in at-risk individuals.

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Year:

2022

PTX3 structure determination using a hybrid cryoelectron microscopy and AlphaFold approach offers insights into ligand binding and complement activation.

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Year:

2022

B-cell activating factor and IL-21 levels predict treatment response in autoimmune hepatitis

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Year:

2022

Autoantibodies against specific post-translationally modified proteins are present in patients with lupus and associate with major neuropsychiatric manifestations

Article Link

Year:

2022

Circulating Levels of Anti-C1q and Anti-Factor H Autoantibodies and Their Targets in Normal Pregnancy and Preeclampsia.

Article Link

Year:

2022

Anti-carbamylated protein antibodies positivity and disease activity in Hispanic patients with established rheumatoid arthritis: An observational study

Article Link

Year:

2022

Initial properdin binding contributes to alternative pathway activation at the surface of viable and necrotic cells.

Article Link

Year:

2022

Circulating C1q levels in health and disease, more than just a biomarker

Article Link

Year:

2021

Collaborators14

Peter van Veelen

Leiden University Medical Center

NETHERLANDS

Annemieke Geluk

Professor Immunodiagnostic of Mycobacterial Diseases

Leiden University Medical Center

NETHERLANDS

Cornelis Hokke

Professor

Leiden University Medical Center

NETHERLANDS

Leonie Taams

King’s College London

UNITED KINGDOM

frederique ponchel

Associate Professor tenured

University of Leeds

UNITED KINGDOM

Jutte J.C. de Vries

Associate Professor (Clinical Virology)

Leiden University Medical Center

NETHERLANDS

Paul J. Hensbergen

Leiden University Medical Center

NETHERLANDS

Cees van Kooten

Professor Experimental Nephrology & Transplant Immunology

LUMC

NETHERLANDS

Frank Staal

professor

Leiden University Medical Center

NETHERLANDS

Simone A Joosten

Associate Professor

Leiden University Medical Center

NETHERLANDS

Y K Onno Teng

Leiden University Medical Center

NETHERLANDS

Thomas H. Sharp

Leiden University Medical Center

NETHERLANDS

Anna Inkeri Lokki

University of Helsinki

FINLAND

Michael Eikmans

Leiden University Medical Center

NETHERLANDS

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